TY - JOUR
T1 - Right Time, Right Place
T2 - Probing the Functions of Organelle Positioning
AU - van Bergeijk, Petra
AU - Hoogenraad, Casper C
AU - Kapitein, Lukas C
N1 - Copyright © 2015 Elsevier Ltd. All rights reserved.
PY - 2016
Y1 - 2016
N2 - The proper spatial arrangement of organelles underlies many cellular processes including signaling, polarization, and growth. Despite the importance of local positioning, the precise connection between subcellular localization and organelle function is often not fully understood. To address this, recent studies have developed and employed different strategies to directly manipulate organelle distributions, such as the use of (light-sensitive) heterodimerization to control the interaction between selected organelles and specific motor proteins, adaptor molecules, or anchoring factors. We review here the importance of subcellular localization as well as tools to control local organelle positioning. Because these approaches allow spatiotemporal control of organelle distribution, they will be invaluable tools to unravel local functioning and the mechanisms that control positioning.
AB - The proper spatial arrangement of organelles underlies many cellular processes including signaling, polarization, and growth. Despite the importance of local positioning, the precise connection between subcellular localization and organelle function is often not fully understood. To address this, recent studies have developed and employed different strategies to directly manipulate organelle distributions, such as the use of (light-sensitive) heterodimerization to control the interaction between selected organelles and specific motor proteins, adaptor molecules, or anchoring factors. We review here the importance of subcellular localization as well as tools to control local organelle positioning. Because these approaches allow spatiotemporal control of organelle distribution, they will be invaluable tools to unravel local functioning and the mechanisms that control positioning.
U2 - 10.1016/j.tcb.2015.10.001
DO - 10.1016/j.tcb.2015.10.001
M3 - Article
C2 - 26541125
SN - 0962-8924
VL - 26
SP - 121
EP - 134
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 2
ER -