RIFM fragrance ingredient safety assessment, 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone, CAS Registry number 61315-75-1

A. M. Api, A. Bartlett, D. Belsito, D. Botelho, M. Bruze, A. Bryant-Friedrich, G. A. Burton, M. A. Cancellieri, H. Chon, M. Cronin, S. Crotty, M. L. Dagli, W. Dekant, C. Deodhar, K. Farrell, A. D. Fryer, L. Jones, K. Joshi, A. Lapczynski, D. L. LaskinM. Lavelle, I. Lee, H. Moustakas, J. Muldoon, T. M. Penning, A. H. Piersma, G. Ritacco, N. Sadekar, I. Schember, T. W. Schultz, F. Siddiqi, I. G. Sipes, G. Sullivan*, Y. Thakkar

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

Abstract

The existing information supports the use of this material as described in this safety assessment. 4-(4-Methyl-3-penten-1-yl)-2(5H)-furanone was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety. Data show that 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone is not mutagenic. The clastogenicity endpoint was evaluated using the Threshold of Toxicological Concern (TTC) for the genotoxicity endpoint material, and the exposure to 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone is below the TTC (0.0025 μg/kg/day). The repeated dose, reproductive, and local respiratory toxicity endpoints were evaluated using the TTC for a Cramer Class III material, and the exposure to 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone is below the TTC (0.0015 mg/kg/day, 0.0015 mg/kg/day, and 0.47 mg/day, respectively). The skin sensitization endpoint was completed using the Dermal Sensitization Threshold (DST) for reactive materials (64 μg/cm2); exposure is below the DST. The photoirritation/photoallergenicity endpoints were evaluated based on ultraviolet/visible (UV/Vis) spectra; 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone is not expected to be photoirritating/photoallergenic. The environmental endpoints were evaluated; for the hazard assessment based on the screening data, 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone is not Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards. For the risk assessment, 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone was not able to be risk screened as there were no reported volumes of use (VoU) for either North America or Europe in the 2019 IFRA Survey.

Original languageEnglish
Article number115076
Number of pages6
JournalFood and Chemical Toxicology
Volume194
Early online date3 Nov 2024
DOIs
Publication statusPublished - Dec 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Fingerprint

Dive into the research topics of 'RIFM fragrance ingredient safety assessment, 4-(4-methyl-3-penten-1-yl)-2(5H)-furanone, CAS Registry number 61315-75-1'. Together they form a unique fingerprint.

Cite this