Rhamnose-based glycomimetic for recruitment of endogenous anti-rhamnose antibodies

Nives Hribernik, Fabrizio Chiodo, Roland J. Pieters, Anna Bernardi*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.

Original languageEnglish
Article number153843
JournalTetrahedron Letters
Volume99
DOIs
Publication statusPublished - 8 Jun 2022

Bibliographical note

Funding Information:
Funding: This research was funded by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 765581 (PhD4GlycoDrug).

Publisher Copyright:
© 2022 The Author(s)

Funding

Funding: This research was funded by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 765581 (PhD4GlycoDrug).

Keywords

  • Anti-carbohydrate antibodies
  • Glycomimetics
  • Immunotherapy
  • L-Rhamnose

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