Abstract
Recruitment of natural antibodies towards tumour cells for their elimination by the immune system could be a highly specific and efficacious therapeutic strategy. While natural L-rhamnose has already been explored as a suitable antigen for antibody recruitment, we here report the first rhamnose-based glycomimetic to be used for such purpose. The glycomimetic is designed to be more hydrolytically and enzymatically stable than natural rhamnosides, provides a site for easy further conjugation and proved to capture anti-rhamnose IgG antibodies in serological ELISA assay.
Original language | English |
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Article number | 153843 |
Journal | Tetrahedron Letters |
Volume | 99 |
DOIs | |
Publication status | Published - 8 Jun 2022 |
Bibliographical note
Funding Information:Funding: This research was funded by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 765581 (PhD4GlycoDrug).
Publisher Copyright:
© 2022 The Author(s)
Funding
Funding: This research was funded by the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 765581 (PhD4GlycoDrug).
Keywords
- Anti-carbohydrate antibodies
- Glycomimetics
- Immunotherapy
- L-Rhamnose