Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

Lotte van Andel; Hilde Rosing; Jan Hm Schellens; Jos H Beijnen

doi:10.3390/md16070246

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

Lotte van Andel, Hilde Rosing, Jan Hm Schellens, Jos H Beijnen

Division of Pharmacology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands. [email protected].
Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek, The Netherlands Cancer Institute and MC Slotervaart, 1066 CX Amsterdam, The Netherlands. [email protected].

Research output: Contribution to journal › Review article › peer-review

Abstract

The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.

Original language	English
Article number	246
Journal	Marine Drugs
Volume	16
Issue number	7
DOIs	https://doi.org/10.3390/md16070246
Publication status	Published - 23 Jul 2018

Keywords

Animals
Antineoplastic Agents/chemistry
Aquatic Organisms/chemistry
Biological Assay/methods
Chromatography, Liquid/methods
Drug Discovery/methods
Humans
Neoplasms/drug therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md16070246

van andel2Final published version, 2.27 MB

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title = "Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment",

abstract = "The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.",

keywords = "Animals, Antineoplastic Agents/chemistry, Aquatic Organisms/chemistry, Biological Assay/methods, Chromatography, Liquid/methods, Drug Discovery/methods, Humans, Neoplasms/drug therapy",

author = "{van Andel}, Lotte and Hilde Rosing and Schellens, {Jan Hm} and Beijnen, {Jos H}",

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language = "English",

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T1 - Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

AU - van Andel, Lotte

AU - Rosing, Hilde

AU - Schellens, Jan Hm

AU - Beijnen, Jos H

PY - 2018/7/23

Y1 - 2018/7/23

N2 - The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.

AB - The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles and to link drug concentrations to clinical outcomes. This review outlines the different analytical methods that have been described for marine-derived drugs in cancer treatment hitherto. It focuses on the major parts of the bioanalytical technology, including sample type, sample pre-treatment, separation, detection, and quantification.

KW - Animals

KW - Antineoplastic Agents/chemistry

KW - Aquatic Organisms/chemistry

KW - Biological Assay/methods

KW - Chromatography, Liquid/methods

KW - Drug Discovery/methods

KW - Humans

KW - Neoplasms/drug therapy

U2 - 10.3390/md16070246

DO - 10.3390/md16070246

M3 - Review article

C2 - 30041477

SN - 1660-3397

VL - 16

JO - Marine Drugs

JF - Marine Drugs

IS - 7

M1 - 246

ER -

Review of Chromatographic Bioanalytical Assays for the Quantitative Determination of Marine-Derived Drugs for Cancer Treatment

Abstract

Keywords

UN SDGs

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