Restoring mucosal tolerance by non-digestible oligosaccharides under inflammatory conditions : a key role for galectins

S. de Kivit

Restoring mucosal tolerance by non-digestible oligosaccharides under inflammatory conditions : a key role for galectins

S. de Kivit

Immunopharmacology

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Abstract

The prevalence of inflammatory diseases, including allergy and IBD, are rapidly increasing in Western society. There is a strong need to develop novel preventive and therapeutic strategies to manage these diseases as there is currently no cure. Understanding the immune system and selecting appropriate immune modulators is crucial for generating safe, preventive and potentially therapeutic treatment strategies. This thesis aims at understanding the mucosal immune system of the intestine and modulation of the GALT through observations on changes in immune cell subsets and function resulting from dietary intervention using specific non- digestible oligosaccharides to induce immunological tolerance

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	Utrecht University
Supervisors/Advisors	Garssen, Johan, Primary supervisor Willemsen, Linette, Co-supervisor Kraneveld, Aletta, Co-supervisor
Award date	20 Mar 2013
Publisher	Utrecht University
Print ISBNs	978-90-9027337-2
Publication status	Published - 20 Mar 2013

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title = "Restoring mucosal tolerance by non-digestible oligosaccharides under inflammatory conditions : a key role for galectins",

abstract = "The prevalence of inflammatory diseases, including allergy and IBD, are rapidly increasing in Western society. There is a strong need to develop novel preventive and therapeutic strategies to manage these diseases as there is currently no cure. Understanding the immune system and selecting appropriate immune modulators is crucial for generating safe, preventive and potentially therapeutic treatment strategies. This thesis aims at understanding the mucosal immune system of the intestine and modulation of the GALT through observations on changes in immune cell subsets and function resulting from dietary intervention using specific non- digestible oligosaccharides to induce immunological tolerance",

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N2 - The prevalence of inflammatory diseases, including allergy and IBD, are rapidly increasing in Western society. There is a strong need to develop novel preventive and therapeutic strategies to manage these diseases as there is currently no cure. Understanding the immune system and selecting appropriate immune modulators is crucial for generating safe, preventive and potentially therapeutic treatment strategies. This thesis aims at understanding the mucosal immune system of the intestine and modulation of the GALT through observations on changes in immune cell subsets and function resulting from dietary intervention using specific non- digestible oligosaccharides to induce immunological tolerance

AB - The prevalence of inflammatory diseases, including allergy and IBD, are rapidly increasing in Western society. There is a strong need to develop novel preventive and therapeutic strategies to manage these diseases as there is currently no cure. Understanding the immune system and selecting appropriate immune modulators is crucial for generating safe, preventive and potentially therapeutic treatment strategies. This thesis aims at understanding the mucosal immune system of the intestine and modulation of the GALT through observations on changes in immune cell subsets and function resulting from dietary intervention using specific non- digestible oligosaccharides to induce immunological tolerance

M3 - Doctoral thesis 1 (Research UU / Graduation UU)

SN - 978-90-9027337-2

PB - Utrecht University

ER -

Restoring mucosal tolerance by non-digestible oligosaccharides under inflammatory conditions : a key role for galectins

Abstract

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