Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma

Nicholas W Lukacs, Joost Smit, Dennis Lindell, Matthew Schaller

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Several respiratory viruses have been shown to cause exacerbations of asthma. While the various viral responses likely have common mechanisms of activation, the respiratory syncytial virus (RSV) appears to promote specific responses that on their own can cause severe pulmonary problems. Understanding the mechanisms that promote inappropriate immune responses and local damage may lead to better therapy. The activation and recruitment of T cells that amplify and skew the immune response toward more intense pathology, including mucus production and remodeling of the airways, are likely scenarios that lead to more severe disease and clinical crisis in asthmatic patients. These mechanisms may also contribute to a significant proportion of exacerbations in chronic obstructive pulmonary disease. This review will focus on recent research on specific pathways of RSV-mediated activation of the innate host defense, including chemokine biology and TLR pathways, as well as on acquired immunity.

    Original languageEnglish
    Pages (from-to)68-82
    Number of pages15
    JournalContributions to Microbiology
    Volume14
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Animals
    • Asthma
    • Chemokines
    • Dendritic Cells
    • Disease Models, Animal
    • Humans
    • Immunity, Innate
    • Mice
    • Mucus
    • Respiratory Syncytial Virus Infections
    • Respiratory Syncytial Viruses
    • Toll-Like Receptors

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