Resolving sorting mechanisms into exosomes

Willem Stoorvogel

doi:10.1038/cr.2015.39

Resolving sorting mechanisms into exosomes

Willem Stoorvogel

Strategic Infection Biology Program (SIB) FVM

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.

Original language	English
Journal	Cell Research
DOIs	https://doi.org/10.1038/cr.2015.39
Publication status	Published - 2015

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10.1038/cr.2015.39

resolvingFinal published version, 1.02 MBLicence: Taverne

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title = "Resolving sorting mechanisms into exosomes",

abstract = "The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.",

author = "Willem Stoorvogel",

year = "2015",

doi = "10.1038/cr.2015.39",

language = "English",

journal = "Cell Research",

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AB - The complexity of mechanisms driving protein sorting into exosomes is only beginning to emerge. In a paper recently published in Cell Research, Roucourt et al. report that trimming of heparan sulfate side chains of syndecans by endosomal heparanase facilitates sorting into exosomes by the formation of tight syndecan clusters that are recruited by the multivalent adaptor syntenin to the ALIX-ESCRT sorting machinery at endosomes.

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DO - 10.1038/cr.2015.39

M3 - Article

C2 - 25828531

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JO - Cell Research

JF - Cell Research

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Resolving sorting mechanisms into exosomes

Abstract

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