Repetitieve transcraniële magnetische stimulatie bij therapieresistente depressie; voorstel voor een behandelprotocol

Translated title of the contribution: rTMS for treatment resistant depression - Proposal for a treatment protocol

S. M. Van Belkum*, M. K. De Boer, G. J. Taams, D. J.L.G. Schutter, A. Aleman, R. A. Schoevers, B. C.M. Haarman

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    BACKGROUND: At present, the use of repetitive transcranial magnetic stimulation (ITMS) FOR treatment-resistant depression is sufficiently substantiated to be applied in clinical practice. In the Netherlands, it will be reimbursed when offered in combination with cognitive behavior therapy. AIM Proposal for a clinical treatment protocol for rTMS in The Netherlands. METHOD: A study of the literature and a critical appraisal of available international guidelines for ITMS. RESULTS: rTMS is a safe treatment for patients suffering from a moderate to severe depressive disorder that is relatively treatment-resistant. The duration of the effect is still unknown. It is advised to stimulate the left dorsolateral prefrontal cortex using an intensity of 120% of the resting motor threshold, with a frequency of 10 Hz and using 3000 pulses per session during a total of 20-30 sessions. CONCLUSION: The proposed treatment protocol is favored based on the available evidence when rrMS is used as a treatment aimed to acutely decrease the severity of depressive symptoms. It is further proposed to systematically collect technical and outcome data on treatment with ITMS to further improve treatment with ITMS in clinical practice.

    Translated title of the contributionrTMS for treatment resistant depression - Proposal for a treatment protocol
    Original languageDutch
    Pages (from-to)766-773
    Number of pages8
    JournalTijdschrift voor Psychiatrie
    Volume60
    Issue number11
    Publication statusPublished - Nov 2018

    Bibliographical note

    Publisher Copyright:
    © 2018 Uitgeverij Boom. All rights reserved.

    Keywords

    • Major depressive disorder
    • Neuromodulation
    • Repetitive transcranial magnetic stimulation
    • RTMS
    • Treatment resistant depression

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