Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results

U.M.H. Klumpers; D.J. Veltman; M.L. Drent; R. Boellaard; E.F.I. Comans; G. Meynen; A.A. Lammertsma; W.J.G. Hoogendijk

doi:10.1007/s00259-009-1292-9

Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results

U.M.H. Klumpers, D.J. Veltman, M.L. Drent, R. Boellaard, E.F.I. Comans, G. Meynen, A.A. Lammertsma, W.J.G. Hoogendijk

Leerstoel Buskens

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Purpose: Major depressive disorder (MDD) has been related to both a dysfunctional γ-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA

Original language	English
Pages (from-to)	565-574
Number of pages	10
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	37
Issue number	3
DOIs	https://doi.org/10.1007/s00259-009-1292-9
Publication status	Published - 2010

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Klumpers, U. M. H., Veltman, D. J., Drent, M. L., Boellaard, R., Comans, E. F. I., Meynen, G., Lammertsma, A. A., & Hoogendijk, W. J. G. (2010). Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results. European Journal of Nuclear Medicine and Molecular Imaging, 37(3), 565-574. https://doi.org/10.1007/s00259-009-1292-9

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abstract = "Purpose: Major depressive disorder (MDD) has been related to both a dysfunctional γ-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA",

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AU - Klumpers, U.M.H.

AU - Veltman, D.J.

AU - Drent, M.L.

AU - Boellaard, R.

AU - Comans, E.F.I.

AU - Meynen, G.

AU - Lammertsma, A.A.

AU - Hoogendijk, W.J.G.

PY - 2010

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N2 - Purpose: Major depressive disorder (MDD) has been related to both a dysfunctional γ-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA

AB - Purpose: Major depressive disorder (MDD) has been related to both a dysfunctional γ-amino butyric acid (GABA) system and to hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA). Although GABA has been suggested to inhibit HPA axis activity, their relationship has never been studied at the level of the central GABA

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DO - 10.1007/s00259-009-1292-9

M3 - Article

SN - 1619-7070

VL - 37

SP - 565

EP - 574

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 3

ER -

Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results

Abstract

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