Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Niloufar Farzan; Susanne J Vijverberg; Anand K Andiappan; Lambang Arianto; Vojko Berce; Natalia Blanca-López; Hans Bisgaard; Klaus Bønnelykke; Esteban G. Burchard; Paloma Campo; Glorisa Canino; Bruce C. Carleton; Juan C Celedón; Fook Tim Chew; Wen Chin Chiang; Michelle M Cloutier; Denis Daley; Herman T den Dekker; F. Nicole Dijk; Liesbeth Duijts; Carlos Flores; Erick Forno; Daniel B Hawcutt; Natalia Hernandez-Pacheco; Johan C de Jongste; Michael Kabesch; Gerard H Koppelman; Vangelis G. Manolopoulos; Erik Melén; Somnath Mukhopadhyay; Sara Nilsson; Colin Na Palmer; Maria Pino-Yanes; Munir Pirmohamed; Uros Potočnik; Jan A Raaijmakers; Katja Repnik; Maximilian Schieck; Yang Yie Sio; Rosalind L Smyth; Csaba Szalai; Kelan G Tantisira; Steve Turner; Marc P van der Schee; Katia M Verhamme; Anke H Maitland-van der Zee

doi:10.2217/pgs-2017-0035

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Niloufar Farzan
, Susanne J Vijverberg
, Anand K Andiappan
, Lambang Arianto
, Vojko Berce
, Natalia Blanca-López
, Hans Bisgaard
, Klaus Bønnelykke
, Esteban G. Burchard
, Paloma Campo
, Glorisa Canino
, Bruce C. Carleton
, Juan C Celedón
, Fook Tim Chew
, Wen Chin Chiang
, Michelle M Cloutier
, Denis Daley
, Herman T den Dekker
, F. Nicole Dijk
, Liesbeth Duijts

Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G. Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin Na Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnik, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee

Academic Medical Center
Singapore Immunology Network, Agency for Science, Technology & Research, Singapore 138648, Singapore.
Copenhagen Prospective Studies on Asthma in Childhood, Herlev & Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Centre for Human Molecular Genetics & Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Allergy Service, Infanta Leonor Hospital, Madrid, Spain.
Departments of Medicine, Bioengineering & Therapeutic Sciences University of California, San Francisco, CA 94110, USA.
Allergy Unit, IBIMA, Regional University Hospital of Malaga, Malaga, Spain.
Behavioral Sciences institute, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico.
Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Division of Pulmonary Medicine, Allergy, & Immunology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA 15224, USA.
Department of Biological Sciences, National University of Singapore, Singapore, & the Allergy & Immunology Division, Department of Paediatric Medicine, KK Children's Hospital, Singapore.
Asthma Center, Connecticut Children's Medical Center, University of Connecticut Health Center, CT 06106, USA.
Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada.
ISGlobal Center for Research in Environmental Epidemiology, Doctor Aiguader 88, 08003 Barcelona, Spain; Pompeu Fabra University, Carrer Ramon Trias Fargas, 25-27, 08005 Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5, Madrid, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
University of Groningen, University Medical Center Groningen, Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children's Hospital, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.
Department of Pediatrics, Division of Neonatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Department of Women's & Children's Health, University of Liverpool, Liverpool, UK.
Erasmus University Medical Center Rotterdam
Department of Pediatric Pneumology & Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden.
Population Pharmacogenetics Group, Biomedical Research Institute, Ninewells Hospital & Medical School University of Dundee, Dundee, UK.
Department of Molecular & Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Faculty for Chemistry & Chemical Engineering, University of Maribor, Maribor, Slovenia.
Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Great Ormond Street Institute of Child Health, University College London, London, UK.
Central Laboratory, Heim Pal Children Hospital, Budapest, Hungary.
Division of Pulmonary & Critical Care Medicine, Brigham & Women's Hospital & Harvard Medical School, Boston, MA 02115, USA.
University of Aberdeen
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.

MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.

RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.

CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

Original language	English
Pages (from-to)	931-943
Number of pages	13
Journal	Pharmacogenomics
Volume	18
Issue number	10
DOIs	https://doi.org/10.2217/pgs-2017-0035
Publication status	Published - Jul 2017

Keywords

asthma
children
consortium
genetics
pharmacogenomics
treatment

Access to Document

10.2217/pgs-2017-0035

Rationale and Design of the Multiethnic Pharmacogenomics in Childhood Asthma ConsortiumFinal published version, 1.08 MBLicence: Taverne

Cite this

Farzan, N., Vijverberg, S. J., Andiappan, A. K., Arianto, L., Berce, V., Blanca-López, N., Bisgaard, H., Bønnelykke, K., Burchard, E. G., Campo, P., Canino, G., Carleton, B. C., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Daley, D., den Dekker, H. T., Dijk, F. N., ... Maitland-van der Zee, A. H. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics, 18(10), 931-943. https://doi.org/10.2217/pgs-2017-0035

@article{2472ac7743c141e7810217272936d0ee,

title = "Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium",

abstract = "AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS \& METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58\% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.",

keywords = "asthma, children, consortium, genetics , pharmacogenomics, treatment",

author = "Niloufar Farzan and Vijverberg, \{Susanne J\} and Andiappan, \{Anand K\} and Lambang Arianto and Vojko Berce and Natalia Blanca-L{\'o}pez and Hans Bisgaard and Klaus B{\o}nnelykke and Burchard, \{Esteban G.\} and Paloma Campo and Glorisa Canino and Carleton, \{Bruce C.\} and Celed{\'o}n, \{Juan C\} and Chew, \{Fook Tim\} and Chiang, \{Wen Chin\} and Cloutier, \{Michelle M\} and Denis Daley and \{den Dekker\}, \{Herman T\} and Dijk, \{F. Nicole\} and Liesbeth Duijts and Carlos Flores and Erick Forno and Hawcutt, \{Daniel B\} and Natalia Hernandez-Pacheco and \{de Jongste\}, \{Johan C\} and Michael Kabesch and Koppelman, \{Gerard H\} and Manolopoulos, \{Vangelis G.\} and Erik Mel{\'e}n and Somnath Mukhopadhyay and Sara Nilsson and Palmer, \{Colin Na\} and Maria Pino-Yanes and Munir Pirmohamed and Uros Poto{\v c}nik and Raaijmakers, \{Jan A\} and Katja Repnik and Maximilian Schieck and Sio, \{Yang Yie\} and Smyth, \{Rosalind L\} and Csaba Szalai and Tantisira, \{Kelan G\} and Steve Turner and \{van der Schee\}, \{Marc P\} and Verhamme, \{Katia M\} and \{Maitland-van der Zee\}, \{Anke H\}",

year = "2017",

month = jul,

doi = "10.2217/pgs-2017-0035",

language = "English",

volume = "18",

pages = "931--943",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Taylor and Francis",

number = "10",

}

Farzan, N, Vijverberg, SJ, Andiappan, AK, Arianto, L, Berce, V, Blanca-López, N, Bisgaard, H, Bønnelykke, K, Burchard, EG, Campo, P, Canino, G, Carleton, BC, Celedón, JC, Chew, FT, Chiang, WC, Cloutier, MM, Daley, D, den Dekker, HT, Dijk, FN, Duijts, L, Flores, C, Forno, E, Hawcutt, DB, Hernandez-Pacheco, N, de Jongste, JC, Kabesch, M, Koppelman, GH, Manolopoulos, VG, Melén, E, Mukhopadhyay, S, Nilsson, S, Palmer, CN, Pino-Yanes, M, Pirmohamed, M, Potočnik, U, Raaijmakers, JA, Repnik, K, Schieck, M, Sio, YY, Smyth, RL, Szalai, C, Tantisira, KG, Turner, S, van der Schee, MP, Verhamme, KM & Maitland-van der Zee, AH 2017, 'Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium', Pharmacogenomics, vol. 18, no. 10, pp. 931-943. https://doi.org/10.2217/pgs-2017-0035

TY - JOUR

T1 - Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

AU - Farzan, Niloufar

AU - Vijverberg, Susanne J

AU - Andiappan, Anand K

AU - Arianto, Lambang

AU - Berce, Vojko

AU - Blanca-López, Natalia

AU - Bisgaard, Hans

AU - Bønnelykke, Klaus

AU - Burchard, Esteban G.

AU - Campo, Paloma

AU - Canino, Glorisa

AU - Carleton, Bruce C.

AU - Celedón, Juan C

AU - Chew, Fook Tim

AU - Chiang, Wen Chin

AU - Cloutier, Michelle M

AU - Daley, Denis

AU - den Dekker, Herman T

AU - Dijk, F. Nicole

AU - Duijts, Liesbeth

AU - Flores, Carlos

AU - Forno, Erick

AU - Hawcutt, Daniel B

AU - Hernandez-Pacheco, Natalia

AU - de Jongste, Johan C

AU - Kabesch, Michael

AU - Koppelman, Gerard H

AU - Manolopoulos, Vangelis G.

AU - Melén, Erik

AU - Mukhopadhyay, Somnath

AU - Nilsson, Sara

AU - Palmer, Colin Na

AU - Pino-Yanes, Maria

AU - Pirmohamed, Munir

AU - Potočnik, Uros

AU - Raaijmakers, Jan A

AU - Repnik, Katja

AU - Schieck, Maximilian

AU - Sio, Yang Yie

AU - Smyth, Rosalind L

AU - Szalai, Csaba

AU - Tantisira, Kelan G

AU - Turner, Steve

AU - van der Schee, Marc P

AU - Verhamme, Katia M

AU - Maitland-van der Zee, Anke H

PY - 2017/7

Y1 - 2017/7

N2 - AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

AB - AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium.MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire.RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed.CONCLUSION: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.

KW - asthma

KW - children

KW - consortium

KW - genetics

KW - pharmacogenomics

KW - treatment

U2 - 10.2217/pgs-2017-0035

DO - 10.2217/pgs-2017-0035

M3 - Article

C2 - 28639505

SN - 1462-2416

VL - 18

SP - 931

EP - 943

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 10

ER -

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium

Abstract

Keywords

Access to Document

Fingerprint

Cite this