Quality of INR control and outcomes following venous thromboembolism

Arlene M Gallagher, Frank de Vries, Jonathan M Plumb, Bastian Haß, Andreas Clemens, Tjeerd-Pieter van Staa

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

INTRODUCTION: The objective of this study was to evaluate the pattern of anticoagulation after venous thromboembolism (VTE) in actual clinical practice.

MATERIAL AND METHODS: This study used the General Practice Research Database. Individuals aged 18+ years with VTE were matched to 3 controls.

RESULTS: Of the 46 335 patients with VTE and 138 024 controls, 70.2% of cases and 86.6% of controls had no obvious risk factors. The mortality risk was increased substantially around the time of diagnosis (relative hazard rate [RR] around 21) but remained elevated for a further 4 years (RRs around 1.5-2.0). The mean percentage of time spent within the therapeutic range for international normalized ratio (INR) was 57.0%. The lowest rate of VTE recurrence occurred in patients with ≥70% time spent within therapeutic range (RR of 0.50, 95% CI 0.39-0.63 compared to <30%).

CONCLUSIONS: Higher time spent within therapeutic INR range was associated with lower risks of VTE recurrence and death due to VTE.

Original languageEnglish
Pages (from-to)370-8
Number of pages9
JournalClinical and Applied Thrombosis/Hemostasis
Volume18
Issue number4
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anticoagulants
  • Databases, Factual
  • Female
  • Great Britain
  • Humans
  • Incidence
  • International Normalized Ratio
  • Male
  • Middle Aged
  • Risk Factors
  • Thromboembolism

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