Proteomic analysis of serum in workers exposed to diesel engine exhaust

M.L. Rahman*, Bryan A. Bassig, Yufei Dai, Jason Y Y Wong, Batel Blechter, H. Dean Hosgood, Danzhi Ren, Huawei Duan, Yong Niu, Jun Xu, Wei Fu, Kees Meliefste, Baosen Zhou, Jufang Yang, Meng Ye, Xiaowei Jia, Tao Meng, Tao Meng, Ping Bin, D.T. SilvermanRoel Vermeulen, Nat Rothman, Yuxin Zheng*, Qing Lan

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using a targeted proteomics approach, we aimed to identify proteins associated with DEE and characterize these markers to understand the mechanisms of DEE-induced carcinogenicity. In this cross-sectional molecular epidemiology study, we measured elemental carbon (EC) using a personal air monitor and quantified 1317 targeted proteins in the serum using the SOMAScan assay (SOMALogic) among 19 diesel exposed factory workers and 19 unexposed controls. We used linear regressions to identify proteins associated with DEE and examined their exposure-response relationship across levels of EC using linear trend tests. We further examined pathway enrichment of DEE-related proteins using MetaCore. Occupational exposure to DEE was associated with altered levels of 22 serum proteins (permutation p 
Original languageEnglish
Pages (from-to)18-28
Number of pages11
JournalEnvironmental and Molecular Mutagenesis
Volume63
Issue number1
Early online date28 Dec 2021
DOIs
Publication statusPublished - Jan 2022

Keywords

  • SOMAscan
  • carcinogenesis
  • diesel engine exhaust
  • Elemental carbon
  • lung cancer
  • proteomics

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