Abstract
Diesel engine exhaust (DEE) is classified as a Group 1 human carcinogen. Using a targeted proteomics approach, we aimed to identify proteins associated with DEE and characterize these markers to understand the mechanisms of DEE-induced carcinogenicity. In this cross-sectional molecular epidemiology study, we measured elemental carbon (EC) using a personal air monitor and quantified 1317 targeted proteins in the serum using the SOMAScan assay (SOMALogic) among 19 diesel exposed factory workers and 19 unexposed controls. We used linear regressions to identify proteins associated with DEE and examined their exposure-response relationship across levels of EC using linear trend tests. We further examined pathway enrichment of DEE-related proteins using MetaCore. Occupational exposure to DEE was associated with altered levels of 22 serum proteins (permutation p
Original language | English |
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Pages (from-to) | 18-28 |
Number of pages | 11 |
Journal | Environmental and Molecular Mutagenesis |
Volume | 63 |
Issue number | 1 |
Early online date | 28 Dec 2021 |
DOIs | |
Publication status | Published - Jan 2022 |
Keywords
- SOMAscan
- carcinogenesis
- diesel engine exhaust
- Elemental carbon
- lung cancer
- proteomics