Protein–Protein Docking with HADDOCK

C. Schmitz; A.S.J. Melquiond; S.J. de Vries; E. Karaca; M. van Dijk; P. Kastritis; A.M.J.J. Bonvin

doi:10.1002/9783527644506.ch32

Protein–Protein Docking with HADDOCK

C. Schmitz, A.S.J. Melquiond, S.J. de Vries, E. Karaca, M. van Dijk, P. Kastritis, A.M.J.J. Bonvin

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Abstract

Advances in biophysics and biochemistry have pushed back the limits of the structural characterization of biomolecular assemblies. Mixing even a limited amount of experimental and/or bioinformatics data with modeling methods such as macromolecular docking represents a valuable strategy to predict the three-dimensional structures of complexes. In this chapter, we discuss the HADDOCK data-driven approach to the modeling of complexes. The program supports a wide range of NMR and other experimental data as well as bioinformatics predictions. It is also available as a user-friendly web server, facilitating the modeling of biomolecular complexes for a wide community.

Original language	English
Title of host publication	NMR of biomolecules : towards mechanistic systems biology
Editors	Ivano Bertini, Kathleen S. McGreevy, Giacomo Parigi
Place of Publication	Weinheim
Publisher	Wiley
Pages	520-535
Number of pages	612
ISBN (Electronic)	9783527644506
ISBN (Print)	9783527328505
DOIs	https://doi.org/10.1002/9783527644506.ch32
Publication status	Published - 14 Mar 2012

Keywords

protein–protein docking
HADDOCK
bioinformatics
macromolecular docking
three-dimensional structure
web server
biomolecular modeling

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10.1002/9783527644506.ch32

Protein protein interactionsFinal published version, 361 KB

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AU - Schmitz, C.

AU - Melquiond, A.S.J.

AU - de Vries, S.J.

AU - Karaca, E.

AU - van Dijk, M.

AU - Kastritis, P.

AU - Bonvin, A.M.J.J.

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KW - HADDOCK

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Protein–Protein Docking with HADDOCK

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