Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels

F. van de Manakker; K. Braeckmans; N. el Morabit; S.C. De Smedt; C.F. van Nostrum; W.E. Hennink

Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels

F. van de Manakker
, K. Braeckmans
, N. el Morabit
, S.C. De Smedt
, C.F. van Nostrum
, W.E. Hennink

Dept of Pharmaceutical Sciences

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

This paper reports on the degradation and protein release behavior of a self-assembled hydrogel system composed of beta-cyclodextrin- (beta CD) and cholesterol-derivatized 8-arm star-shaped poly(ethylene glycol) (PEG(8)). By mixing beta CD- and cholesterol-derivatized PEG(8) (molecular weights 10, 20 and 40 kDa) in aqueous solution, hydrogels with different rheological properties are formed. it is shown that hydrogel degradation is mainly the result of surface erosion, which depends on the network swelling stresses and initial crosslink density of the gels. This degradation mechanism, which is hardly observed for other water-absorbing polymer networks, leads to a quantitative and nearly zero-order release of entrapped proteins. This system therefore offers great potential for protein delivery.

Original language	Undefined/Unknown
Pages (from-to)	2992-3001
Number of pages	10
Journal	Advanced Functional Materials
Volume	19
Issue number	18
Publication status	Published - 2009

Bibliographical note

ISI:000270438100016
TiPharma Spring meeting

Keywords

Farmacie/Biofarmaceutische wetenschappen (FARM)
Medical technology
Farmacie(FARM)
Biomedische technologie en medicijnen
Pharmacology

Cite this

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title = "Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels",

abstract = "This paper reports on the degradation and protein release behavior of a self-assembled hydrogel system composed of beta-cyclodextrin- (beta CD) and cholesterol-derivatized 8-arm star-shaped poly(ethylene glycol) (PEG(8)). By mixing beta CD- and cholesterol-derivatized PEG(8) (molecular weights 10, 20 and 40 kDa) in aqueous solution, hydrogels with different rheological properties are formed. it is shown that hydrogel degradation is mainly the result of surface erosion, which depends on the network swelling stresses and initial crosslink density of the gels. This degradation mechanism, which is hardly observed for other water-absorbing polymer networks, leads to a quantitative and nearly zero-order release of entrapped proteins. This system therefore offers great potential for protein delivery.",

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author = "\{van de Manakker\}, F. and K. Braeckmans and \{el Morabit\}, N. and \{De Smedt\}, S.C. and \{van Nostrum\}, C.F. and W.E. Hennink",

note = "ISI:000270438100016 TiPharma Spring meeting",

year = "2009",

language = "Undefined/Unknown",

volume = "19",

pages = "2992--3001",

journal = "Advanced Functional Materials",

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TY - JOUR

T1 - Protein-Release Behavior of Self-Assembled PEG-beta-Cyclodextrin/PEG-Cholesterol Hydrogels

AU - van de Manakker, F.

AU - Braeckmans, K.

AU - el Morabit, N.

AU - De Smedt, S.C.

AU - van Nostrum, C.F.

AU - Hennink, W.E.

N1 - ISI:000270438100016 TiPharma Spring meeting

PY - 2009

Y1 - 2009

N2 - This paper reports on the degradation and protein release behavior of a self-assembled hydrogel system composed of beta-cyclodextrin- (beta CD) and cholesterol-derivatized 8-arm star-shaped poly(ethylene glycol) (PEG(8)). By mixing beta CD- and cholesterol-derivatized PEG(8) (molecular weights 10, 20 and 40 kDa) in aqueous solution, hydrogels with different rheological properties are formed. it is shown that hydrogel degradation is mainly the result of surface erosion, which depends on the network swelling stresses and initial crosslink density of the gels. This degradation mechanism, which is hardly observed for other water-absorbing polymer networks, leads to a quantitative and nearly zero-order release of entrapped proteins. This system therefore offers great potential for protein delivery.

AB - This paper reports on the degradation and protein release behavior of a self-assembled hydrogel system composed of beta-cyclodextrin- (beta CD) and cholesterol-derivatized 8-arm star-shaped poly(ethylene glycol) (PEG(8)). By mixing beta CD- and cholesterol-derivatized PEG(8) (molecular weights 10, 20 and 40 kDa) in aqueous solution, hydrogels with different rheological properties are formed. it is shown that hydrogel degradation is mainly the result of surface erosion, which depends on the network swelling stresses and initial crosslink density of the gels. This degradation mechanism, which is hardly observed for other water-absorbing polymer networks, leads to a quantitative and nearly zero-order release of entrapped proteins. This system therefore offers great potential for protein delivery.

KW - Farmacie/Biofarmaceutische wetenschappen (FARM)

KW - Medical technology

KW - Farmacie(FARM)

KW - Biomedische technologie en medicijnen

KW - Pharmacology

M3 - Article

SN - 1616-301X

VL - 19

SP - 2992

EP - 3001

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 18

ER -