Abstract
A correct three-dimensional structure is a prerequisite for protein functionality,
and therefore for life. Thus, it is not surprising that our cells are
packed with proteins that assist protein folding, the process in which the
native three-dimensional structure is formed. In general, plasma membrane
and secreted proteins, as well as those residing in compartments along the
endocytic and exocytic pathways, fold and oligomerize in the endoplasmic
reticulum. The proteins residing in the endoplasmic reticulum are specialized
in the folding of this subset of proteins, which renders this compartment
a protein-folding factory. This review focuses on protein folding in
the endoplasmic reticulum, and discusses the challenge of oligomer formation
in the endoplasmic reticulum as well as the cytosol.
Original language | English |
---|---|
Pages (from-to) | 4700-4727 |
Number of pages | 28 |
Journal | The FEBS journal |
Volume | 275 |
Publication status | Published - 2008 |