Protective immunisation against hepatitis B with an internal antigen of the virus

Kenneth Murray; Sandra A. Bruce; Paul Wingfield; Peer van Eerd; Arie de Reus; Huub Schellekens

doi:10.1002/jmv.1890230202

Protective immunisation against hepatitis B with an internal antigen of the virus

Kenneth Murray^*
, Sandra A. Bruce
, Paul Wingfield
, Peer van Eerd
, Arie de Reus
, Huub Schellekens

^*Corresponding author for this work

University of Edinburgh
Biogen IDEC
Netherlands Organisation for Applied Scientific Research
extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Preparations of hepatitis B virus (HBV) core antigen (HBcAg) synthesised in Escherichia coli have been shown previously to confer partial immunity against infection by the virus Murray, Bruce, Hinnen, Wingfield, van Eerd, de Reus, and Schellekens: EMBO Journal 3: 645–450, 19841. In a further experiment reported here, immunisation of chimpanzees with a similar preparation of HBcAg that had been treated with sodium dodecyl sulphate in order to expose e antigen epitopes was found to protect one animal completely and another quite substantially upon challenge with the virus. The results are used to support the argument for trials in humans of a vaccine against HBV based upon or containing HBcAg and its e antigen derivative, and in discussion of a more general role for internal antigens in generating immunity against viral infection.

Original language	English
Pages (from-to)	101-107
Number of pages	7
Journal	Journal of Medical Virology
Volume	23
Issue number	2
DOIs	https://doi.org/10.1002/jmv.1890230202
Publication status	Published - 1 Jan 1987
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

core antigen
e antigen
HBV
vaccination

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10.1002/jmv.1890230202

Cite this

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title = "Protective immunisation against hepatitis B with an internal antigen of the virus",

abstract = "Preparations of hepatitis B virus (HBV) core antigen (HBcAg) synthesised in Escherichia coli have been shown previously to confer partial immunity against infection by the virus Murray, Bruce, Hinnen, Wingfield, van Eerd, de Reus, and Schellekens: EMBO Journal 3: 645–450, 19841. In a further experiment reported here, immunisation of chimpanzees with a similar preparation of HBcAg that had been treated with sodium dodecyl sulphate in order to expose e antigen epitopes was found to protect one animal completely and another quite substantially upon challenge with the virus. The results are used to support the argument for trials in humans of a vaccine against HBV based upon or containing HBcAg and its e antigen derivative, and in discussion of a more general role for internal antigens in generating immunity against viral infection.",

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doi = "10.1002/jmv.1890230202",

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AU - Murray, Kenneth

AU - Bruce, Sandra A.

AU - Wingfield, Paul

AU - van Eerd, Peer

AU - de Reus, Arie

AU - Schellekens, Huub

PY - 1987/1/1

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AB - Preparations of hepatitis B virus (HBV) core antigen (HBcAg) synthesised in Escherichia coli have been shown previously to confer partial immunity against infection by the virus Murray, Bruce, Hinnen, Wingfield, van Eerd, de Reus, and Schellekens: EMBO Journal 3: 645–450, 19841. In a further experiment reported here, immunisation of chimpanzees with a similar preparation of HBcAg that had been treated with sodium dodecyl sulphate in order to expose e antigen epitopes was found to protect one animal completely and another quite substantially upon challenge with the virus. The results are used to support the argument for trials in humans of a vaccine against HBV based upon or containing HBcAg and its e antigen derivative, and in discussion of a more general role for internal antigens in generating immunity against viral infection.

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Protective immunisation against hepatitis B with an internal antigen of the virus

Abstract

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Keywords

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