Abstract

Members of the genus Bartonella are fastidious Gram-negative facultative intracellular bacteria that are typically transmitted by arthropod vectors. Several Bartonella spp. have been found to cause culture-negative endocarditis in humans. Here, we report the case of a 75-year old German woman with prosthetic valve endocarditis due to Bartonella washoensis. The infecting agent was characterized by sequencing of six housekeeping genes (16S rRNA, ftsZ, gltA, groEL, ribC, rpoB) applying a multilocus sequence typing (MLST) approach. The 5097 bp of the concatenated housekeeping gene sequence from the patient were 99.0% identical to a B. washoensis strain from a red squirrel (Sciurus vulgaris orientis) from China. 39% (24/62) of red squirrel (S. vulgaris) samples from the Netherlands were positive for the B. washoensis gltA gene variant detected in the patient. This suggests that the red squirrel is the reservoir host for human infection in Europe.

Original languageEnglish
Article numbere01404-19
Number of pages9
JournalJournal of Clinical Microbiology
Volume58
Issue number1
Early online date2019
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Bartonella washoensis
  • Europe
  • Sciurus vulgaris
  • endocarditis
  • human
  • multilocus sequence typing (MLST)
  • red squirrel
  • reservoir

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