TY - JOUR
T1 - Prognostic value of the PDLIM family in acute myeloid leukemia
AU - Cui, Longzhen
AU - Cheng, Zhiheng
AU - Hu, Kai
AU - Pang, Yifan
AU - Liu, Yan
AU - Qian, Tingting
AU - Quan, Liang
AU - Dai, Yifeng
AU - Pang, Ying
AU - Ye, Xu
AU - Shi, Jinlong
AU - Fu, Lin
PY - 2019
Y1 - 2019
N2 - Acute myeloid leukemia (AML) is a genetically complex, highly aggressive hematological malignancy. Prognosis is usually with grim. PDZ and LIM domain proteins (PDLIM) are involved in the regulation of a variety of biological processes, including cytoskeletal organization, cell differentiation, organ development, neural signaling or tumorigenesis. The clinical and prognostic value of the PDLIM family in AML is unclear. To understand the role of PDLIM expression in AML, The Cancer Genome Atlas (TCGA) database was screened and 155 de novo AML patients with complete clinical information and the expression data of the PDLIM family were included in the study. The clinical and molecular characteristics associated with the expression of different members of the PDLIM family were summarized using various statistical methods. In 84 patients who only received chemotherapy, univariate analysis indicated that high expression of PDLIM2 or PDLIM7 was associated with shorter EFS and OS (both P
AB - Acute myeloid leukemia (AML) is a genetically complex, highly aggressive hematological malignancy. Prognosis is usually with grim. PDZ and LIM domain proteins (PDLIM) are involved in the regulation of a variety of biological processes, including cytoskeletal organization, cell differentiation, organ development, neural signaling or tumorigenesis. The clinical and prognostic value of the PDLIM family in AML is unclear. To understand the role of PDLIM expression in AML, The Cancer Genome Atlas (TCGA) database was screened and 155 de novo AML patients with complete clinical information and the expression data of the PDLIM family were included in the study. The clinical and molecular characteristics associated with the expression of different members of the PDLIM family were summarized using various statistical methods. In 84 patients who only received chemotherapy, univariate analysis indicated that high expression of PDLIM2 or PDLIM7 was associated with shorter EFS and OS (both P
UR - https://research.rug.nl/en/publications/c7121cf3-4dbb-4eff-afbd-f25793bea38c
M3 - Article
SN - 1943-8141
VL - 11
SP - 6124
EP - 6131
JO - American Journal of Translational Research
JF - American Journal of Translational Research
IS - 9
ER -
