Prognostic value of HMGN family expression in acute myeloid leukemia

Wei Cui; Yuna Liu; Yanan Tan; Xingyue Peng; Longzhen Cui; Zhiheng Cheng; Yifeng Dai; Lin Fu; Tiansheng Zeng; Yan Liu

doi:10.2217/fon-2020-0555

Prognostic value of HMGN family expression in acute myeloid leukemia

Wei Cui
, Yuna Liu
, Yanan Tan
, Xingyue Peng
, Longzhen Cui
, Zhiheng Cheng
, Yifeng Dai
, Lin Fu
, Tiansheng Zeng^*
, Yan Liu^*

^*Corresponding author for this work

extern

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aim: The objective of this work was to investigate the prognostic role of the HMGN family in acute myeloid leukemia (AML). Methods: A total of 155 AML patients with HMGN1-5 expression data from the Cancer Genome Atlas database were enrolled in this study. Results: In the chemotherapy-only group, patients with high HMGN2 expression had significantly longer event-free survival (EFS) and overall survival (OS) than those with low expression (all p < 0.05), whereas high HMGN5 expressers had shorter EFS and OS than the low expressers (all p < 0.05). Multivariate analysis identified that high HMGN2 expression was an independent favorable prognostic factor for patients who only received chemotherapy (all p < 0.05). HMGN family expression had no impact on EFS and OS in AML patients receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 expression is a potential prognostic indicator for AML.

Original language	English
Pages (from-to)	541-548
Journal	Future Oncology
Volume	17
Issue number	5
DOIs	https://doi.org/10.2217/fon-2020-0555
Publication status	Published - Feb 2021
Externally published	Yes

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10.2217/fon-2020-0555

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@article{daf622b3ffdb4b1a851bc90284429aa2,

title = "Prognostic value of HMGN family expression in acute myeloid leukemia",

abstract = "Aim: The objective of this work was to investigate the prognostic role of the HMGN family in acute myeloid leukemia (AML). Methods: A total of 155 AML patients with HMGN1-5 expression data from the Cancer Genome Atlas database were enrolled in this study. Results: In the chemotherapy-only group, patients with high HMGN2 expression had significantly longer event-free survival (EFS) and overall survival (OS) than those with low expression (all p < 0.05), whereas high HMGN5 expressers had shorter EFS and OS than the low expressers (all p < 0.05). Multivariate analysis identified that high HMGN2 expression was an independent favorable prognostic factor for patients who only received chemotherapy (all p < 0.05). HMGN family expression had no impact on EFS and OS in AML patients receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 expression is a potential prognostic indicator for AML.",

author = "Wei Cui and Yuna Liu and Yanan Tan and Xingyue Peng and Longzhen Cui and Zhiheng Cheng and Yifeng Dai and Lin Fu and Tiansheng Zeng and Yan Liu",

year = "2021",

month = feb,

doi = "10.2217/fon-2020-0555",

language = "English",

volume = "17",

pages = "541--548",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Taylor and Francis",

number = "5",

}

TY - JOUR

T1 - Prognostic value of HMGN family expression in acute myeloid leukemia

AU - Cui, Wei

AU - Liu, Yuna

AU - Tan, Yanan

AU - Peng, Xingyue

AU - Cui, Longzhen

AU - Cheng, Zhiheng

AU - Dai, Yifeng

AU - Fu, Lin

AU - Zeng, Tiansheng

AU - Liu, Yan

PY - 2021/2

Y1 - 2021/2

N2 - Aim: The objective of this work was to investigate the prognostic role of the HMGN family in acute myeloid leukemia (AML). Methods: A total of 155 AML patients with HMGN1-5 expression data from the Cancer Genome Atlas database were enrolled in this study. Results: In the chemotherapy-only group, patients with high HMGN2 expression had significantly longer event-free survival (EFS) and overall survival (OS) than those with low expression (all p < 0.05), whereas high HMGN5 expressers had shorter EFS and OS than the low expressers (all p < 0.05). Multivariate analysis identified that high HMGN2 expression was an independent favorable prognostic factor for patients who only received chemotherapy (all p < 0.05). HMGN family expression had no impact on EFS and OS in AML patients receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 expression is a potential prognostic indicator for AML.

AB - Aim: The objective of this work was to investigate the prognostic role of the HMGN family in acute myeloid leukemia (AML). Methods: A total of 155 AML patients with HMGN1-5 expression data from the Cancer Genome Atlas database were enrolled in this study. Results: In the chemotherapy-only group, patients with high HMGN2 expression had significantly longer event-free survival (EFS) and overall survival (OS) than those with low expression (all p < 0.05), whereas high HMGN5 expressers had shorter EFS and OS than the low expressers (all p < 0.05). Multivariate analysis identified that high HMGN2 expression was an independent favorable prognostic factor for patients who only received chemotherapy (all p < 0.05). HMGN family expression had no impact on EFS and OS in AML patients receiving allogeneic hematopoietic stem cell transplantation. Conclusion: High HMGN2/5 expression is a potential prognostic indicator for AML.

UR - https://research.rug.nl/en/publications/5ba6759c-a3b8-4c45-86c6-0c2344818cf0

U2 - 10.2217/fon-2020-0555

DO - 10.2217/fon-2020-0555

M3 - Article

SN - 1479-6694

VL - 17

SP - 541

EP - 548

JO - Future Oncology

JF - Future Oncology

IS - 5

ER -

Prognostic value of HMGN family expression in acute myeloid leukemia

Abstract

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