Abstract
Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4and C4and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 401-408 |
| Number of pages | 8 |
| Journal | Inflammation |
| Volume | 14 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 26 Jan 1990 |
Keywords
- arachidonic acid
- leukotriene
- linoleic acid
- animal cell
- article
- metabolism
- nonhuman
- priority journal
- swine
- trachea mucosa