Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System

Herman Autrup; Frank A. Barile; Bas J. Blaauboer; Gisela H. Degen; Wolfgang Dekant; Daniel Dietrich; Jose L. Domingo; Gio Batta Gori; Helmuth Greim; Jan G. Hengstler; Sam Kacew; Hans Marquardt; Olavi Pelkonen; Kai Savolainen; Nico P. Vermeulen

doi:10.1093/toxsci/kfv082

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System

Herman Autrup, Frank A. Barile, Bas J. Blaauboer, Gisela H. Degen, Wolfgang Dekant^*, Daniel Dietrich, Jose L. Domingo, Gio Batta Gori, Helmuth Greim, Jan G. Hengstler, Sam Kacew, Hans Marquardt, Olavi Pelkonen, Kai Savolainen, Nico P. Vermeulen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

Original language	English
Pages (from-to)	11-15
Number of pages	5
Journal	Toxicological Sciences
Volume	146
Issue number	1
DOIs	https://doi.org/10.1093/toxsci/kfv082
Publication status	Published - Jul 2015

Keywords

endocrine disruptors
endocrine toxicology
risk assessment
regulatory/policy
DIETARY 17-BETA-ESTRADIOL E2
HUMAN HEALTH
DISRUPTING CHEMICALS
RISK-ASSESSMENT
BISPHENOL-A
MYCOTOXIN ZEARALENONE
REPRODUCTIVE TOXICITY
FEMALE MICE
SWISS MICE
IN-UTERO

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EndocrineFinal published version, 100 KBLicence: Taverne

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Autrup, H., Barile, F. A., Blaauboer, B. J., Degen, G. H., Dekant, W., Dietrich, D., Domingo, J. L., Gori, G. B., Greim, H., Hengstler, J. G., Kacew, S., Marquardt, H., Pelkonen, O., Savolainen, K., & Vermeulen, N. P. (2015). Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System. Toxicological Sciences, 146(1), 11-15. https://doi.org/10.1093/toxsci/kfv082

@article{00cc294bb0fc4c2b80dc3907bbe4420a,

title = "Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System",

abstract = "The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.",

keywords = "endocrine disruptors, endocrine toxicology, risk assessment, regulatory/policy, DIETARY 17-BETA-ESTRADIOL E2, HUMAN HEALTH, DISRUPTING CHEMICALS, RISK-ASSESSMENT, BISPHENOL-A, MYCOTOXIN ZEARALENONE, REPRODUCTIVE TOXICITY, FEMALE MICE, SWISS MICE, IN-UTERO",

author = "Herman Autrup and Barile, {Frank A.} and Blaauboer, {Bas J.} and Degen, {Gisela H.} and Wolfgang Dekant and Daniel Dietrich and Domingo, {Jose L.} and Gori, {Gio Batta} and Helmuth Greim and Hengstler, {Jan G.} and Sam Kacew and Hans Marquardt and Olavi Pelkonen and Kai Savolainen and Vermeulen, {Nico P.}",

year = "2015",

month = jul,

doi = "10.1093/toxsci/kfv082",

language = "English",

volume = "146",

pages = "11--15",

journal = "Toxicological Sciences",

issn = "1096-6080",

publisher = "Oxford University Press",

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Autrup, H, Barile, FA, Blaauboer, BJ, Degen, GH, Dekant, W, Dietrich, D, Domingo, JL, Gori, GB, Greim, H, Hengstler, JG, Kacew, S, Marquardt, H, Pelkonen, O, Savolainen, K & Vermeulen, NP 2015, 'Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System', Toxicological Sciences, vol. 146, no. 1, pp. 11-15. https://doi.org/10.1093/toxsci/kfv082

TY - JOUR

T1 - Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System

AU - Autrup, Herman

AU - Barile, Frank A.

AU - Blaauboer, Bas J.

AU - Degen, Gisela H.

AU - Dekant, Wolfgang

AU - Dietrich, Daniel

AU - Domingo, Jose L.

AU - Gori, Gio Batta

AU - Greim, Helmuth

AU - Hengstler, Jan G.

AU - Kacew, Sam

AU - Marquardt, Hans

AU - Pelkonen, Olavi

AU - Savolainen, Kai

AU - Vermeulen, Nico P.

PY - 2015/7

Y1 - 2015/7

N2 - The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

AB - The present debate on chemicals with Hormonal activity, often termed 'endocrine disruptors', is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard identification and risk characterization. In our opinion, chemicals with hormonal activity can be subjected to the well-evaluated health risk characterization approach used for many years including adverse outcome pathways. Many of the points arguing for a specific approach for risk characterization of chemicals with hormonal activity are based on highly speculative conclusions. These conclusions are not well supported when evaluating the available information.

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KW - endocrine toxicology

KW - risk assessment

KW - regulatory/policy

KW - DIETARY 17-BETA-ESTRADIOL E2

KW - HUMAN HEALTH

KW - DISRUPTING CHEMICALS

KW - RISK-ASSESSMENT

KW - BISPHENOL-A

KW - MYCOTOXIN ZEARALENONE

KW - REPRODUCTIVE TOXICITY

KW - FEMALE MICE

KW - SWISS MICE

KW - IN-UTERO

U2 - 10.1093/toxsci/kfv082

DO - 10.1093/toxsci/kfv082

M3 - Article

SN - 1096-6080

VL - 146

SP - 11

EP - 15

JO - Toxicological Sciences

JF - Toxicological Sciences

IS - 1

ER -

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System

Abstract

Keywords

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