Primary splenic peripheral nerve sheath tumour in a dog

W Bergmann, I A Burgener, P Roccabianca, U Rytz, M Welle

    Research output: Contribution to journalArticleAcademicpeer-review


    An 8-year-old crossbred dog was presented with a one-month history of progressive weakness, respiratory impairment and abdominal distension. Surgical exploration revealed the presence of a splenic mass that infiltrated the mesentery and was adherent to the stomach and pancreas. The mass was composed of highly cellular areas of spindle-shaped cells arranged in interlacing bundles, streams, whorls and storiform patterns (Antoni A pattern) and less cellular areas with more loosely arranged spindle to oval cells (Antoni B pattern). The majority of neoplastic cells expressed vimentin, S-100 and glial fibrillary acidic protein (GFAP), but did not express desmin, alpha-smooth muscle actin or factor VIII. These morphological and immunohistochemical findings characterized the lesion as a malignant peripheral nerve sheath tumour (PNST). Primary splenic PNST has not been documented previously in the dog.

    Original languageEnglish
    Pages (from-to)195-8
    Number of pages4
    JournalJournal of Comparative Pathology
    Issue number2-3
    Publication statusPublished - 30 May 2009


    • Animals
    • Dog Diseases
    • Dogs
    • Euthanasia, Animal
    • Fatal Outcome
    • Female
    • Glial Fibrillary Acidic Protein
    • Immunohistochemistry
    • Nerve Sheath Neoplasms
    • S100 Proteins
    • Splenic Neoplasms
    • Tumor Markers, Biological
    • Vimentin


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