Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

Riccardo Levato; Miguel A. Mateos-Timoneda; Josep A. Planell

doi:10.1002/mabi.201100383

Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

Riccardo Levato, Miguel A. Mateos-Timoneda^*, Josep A. Planell

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180μm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

Original language	English
Pages (from-to)	557-566
Number of pages	10
Journal	Macromolecular Bioscience
Volume	12
Issue number	4
Early online date	23 Feb 2012
DOIs	https://doi.org/10.1002/mabi.201100383
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

Biocompatibility
Biodegradable
Green solvents
Microparticles
Poly(lactic acid)

Access to Document

10.1002/mabi.201100383

Cite this

@article{384467e3a6b94db582b8e0132e88b31f,

title = "Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure",

abstract = "PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180μm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.",

keywords = "Biocompatibility, Biodegradable, Green solvents, Microparticles, Poly(lactic acid)",

author = "Riccardo Levato and Mateos-Timoneda, {Miguel A.} and Planell, {Josep A.}",

year = "2012",

month = apr,

doi = "10.1002/mabi.201100383",

language = "English",

volume = "12",

pages = "557--566",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

number = "4",

}

TY - JOUR

T1 - Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

AU - Levato, Riccardo

AU - Mateos-Timoneda, Miguel A.

AU - Planell, Josep A.

PY - 2012/4

Y1 - 2012/4

N2 - PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180μm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

AB - PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180μm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.

KW - Biocompatibility

KW - Biodegradable

KW - Green solvents

KW - Microparticles

KW - Poly(lactic acid)

UR - http://www.scopus.com/inward/record.url?scp=84859713181&partnerID=8YFLogxK

U2 - 10.1002/mabi.201100383

DO - 10.1002/mabi.201100383

M3 - Article

C2 - 22362713

AN - SCOPUS:84859713181

SN - 1616-5187

VL - 12

SP - 557

EP - 566

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 4

ER -

Preparation of Biodegradable Polylactide Microparticles via a Biocompatible Procedure

Abstract

Keywords

Access to Document

Fingerprint

Cite this