Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study

Fatemeh Saberi Hosnijeh; Giuseppe Matullo; Alessia Russo; Simonetta Guarrera; Federica Modica; Alexandra Nieters; Kim Overvad; Per Guldberg; Anne Tjønneland; Federico Canzian; Heiner Boeing; Krasimira Aleksandrova; Antonia Trichopoulou; Pagona Lagiou; Dimitrios Trichopoulos; Giovanna Tagliabue; Rosario Tumino; Salvatore Panico; Domenico Palli; Karina Standahl Olsen; Elisabete Weiderpass; Miren Dorronsoro; Eva Ardanaz; Maria Dolores Chirlaque; María José Sánchez; J. Ramón Quirós; Adoración Venceslá; Beatrice Melin; Ann Sofie Johansson; Peter Nilsson; Signe Borgquist; Petra H. Peeters; N. Charlotte Onland-Moret; H. B. Bueno-de-Mesquita; Ruth C. Travis; Kay Tee Khaw; Nick Wareham; Paul Brennan; Pietro Ferrari; Marc J. Gunter; Paolo Vineis; Roel Vermeulen

doi:10.1002/ijc.28934

Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study

Fatemeh Saberi Hosnijeh, Giuseppe Matullo, Alessia Russo, Simonetta Guarrera, Federica Modica, Alexandra Nieters, Kim Overvad, Per Guldberg, Anne Tjønneland, Federico Canzian, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Giovanna Tagliabue, Rosario Tumino, Salvatore Panico, Domenico Palli, Karina Standahl OlsenElisabete Weiderpass, Miren Dorronsoro, Eva Ardanaz, Maria Dolores Chirlaque, María José Sánchez, J. Ramón Quirós, Adoración Venceslá, Beatrice Melin, Ann Sofie Johansson, Peter Nilsson, Signe Borgquist, Petra H. Peeters, N. Charlotte Onland-Moret, H. B. Bueno-de-Mesquita, Ruth C. Travis, Kay Tee Khaw, Nick Wareham, Paul Brennan, Pietro Ferrari, Marc J. Gunter, Paolo Vineis, Roel Vermeulen^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.

Original language	English
Pages (from-to)	2910-2917
Number of pages	8
Journal	International Journal of Cancer
Volume	135
Issue number	12
DOIs	https://doi.org/10.1002/ijc.28934
Publication status	Published - 1 Jan 2014

Keywords

Lymphoma
NHL
Prospective study
Telomeres

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10.1002/ijc.28934

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Hosnijeh, F. S., Matullo, G., Russo, A., Guarrera, S., Modica, F., Nieters, A., Overvad, K., Guldberg, P., Tjønneland, A., Canzian, F., Boeing, H., Aleksandrova, K., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Tagliabue, G., Tumino, R., Panico, S., Palli, D., ... Vermeulen, R. (2014). Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study. International Journal of Cancer, 135(12), 2910-2917. https://doi.org/10.1002/ijc.28934

@article{3bc763c7541a4fb7b27f23ba4d3b7f57,

title = "Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study",

abstract = "Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.",

keywords = "Lymphoma, NHL, Prospective study, Telomeres",

author = "Hosnijeh, {Fatemeh Saberi} and Giuseppe Matullo and Alessia Russo and Simonetta Guarrera and Federica Modica and Alexandra Nieters and Kim Overvad and Per Guldberg and Anne Tj{\o}nneland and Federico Canzian and Heiner Boeing and Krasimira Aleksandrova and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Giovanna Tagliabue and Rosario Tumino and Salvatore Panico and Domenico Palli and Olsen, {Karina Standahl} and Elisabete Weiderpass and Miren Dorronsoro and Eva Ardanaz and Chirlaque, {Maria Dolores} and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Quir{\'o}s, {J. Ram{\'o}n} and Adoraci{\'o}n Vencesl{\'a} and Beatrice Melin and Johansson, {Ann Sofie} and Peter Nilsson and Signe Borgquist and Peeters, {Petra H.} and Onland-Moret, {N. Charlotte} and Bueno-de-Mesquita, {H. B.} and Travis, {Ruth C.} and Khaw, {Kay Tee} and Nick Wareham and Paul Brennan and Pietro Ferrari and Gunter, {Marc J.} and Paolo Vineis and Roel Vermeulen",

year = "2014",

month = jan,

day = "1",

doi = "10.1002/ijc.28934",

language = "English",

volume = "135",

pages = "2910--2917",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "12",

}

Hosnijeh, FS, Matullo, G, Russo, A, Guarrera, S, Modica, F, Nieters, A, Overvad, K, Guldberg, P, Tjønneland, A, Canzian, F, Boeing, H, Aleksandrova, K, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Tagliabue, G, Tumino, R, Panico, S, Palli, D, Olsen, KS, Weiderpass, E, Dorronsoro, M, Ardanaz, E, Chirlaque, MD, Sánchez, MJ, Quirós, JR, Venceslá, A, Melin, B, Johansson, AS, Nilsson, P, Borgquist, S, Peeters, PH, Onland-Moret, NC, Bueno-de-Mesquita, HB, Travis, RC, Khaw, KT, Wareham, N, Brennan, P, Ferrari, P, Gunter, MJ, Vineis, P & Vermeulen, R 2014, 'Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study', International Journal of Cancer, vol. 135, no. 12, pp. 2910-2917. https://doi.org/10.1002/ijc.28934

TY - JOUR

T1 - Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study

AU - Hosnijeh, Fatemeh Saberi

AU - Matullo, Giuseppe

AU - Russo, Alessia

AU - Guarrera, Simonetta

AU - Modica, Federica

AU - Nieters, Alexandra

AU - Overvad, Kim

AU - Guldberg, Per

AU - Tjønneland, Anne

AU - Canzian, Federico

AU - Boeing, Heiner

AU - Aleksandrova, Krasimira

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Tagliabue, Giovanna

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Palli, Domenico

AU - Olsen, Karina Standahl

AU - Weiderpass, Elisabete

AU - Dorronsoro, Miren

AU - Ardanaz, Eva

AU - Chirlaque, Maria Dolores

AU - Sánchez, María José

AU - Quirós, J. Ramón

AU - Venceslá, Adoración

AU - Melin, Beatrice

AU - Johansson, Ann Sofie

AU - Nilsson, Peter

AU - Borgquist, Signe

AU - Peeters, Petra H.

AU - Onland-Moret, N. Charlotte

AU - Bueno-de-Mesquita, H. B.

AU - Travis, Ruth C.

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Brennan, Paul

AU - Ferrari, Pietro

AU - Gunter, Marc J.

AU - Vineis, Paolo

AU - Vermeulen, Roel

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.

AB - Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of BCL. Using quantitative polymerase chain reaction, the relative TL (i.e. the ratio of telomere repeat copy number to single gene copy number) was measured in mononuclear cell DNA of prediagnostic peripheral blood samples of 464 lymphoma cases and 464 matched controls (median time between blood collection and diagnosis, 4.6 years). Conditional logistic regression was used to analyze the association between TL and the risk of developing lymphoma and histologic subtypes. TL was significantly longer in cases compared to controls (p = 0.01). Multivariable models showed a significantly increased risk of BCL [odds ratio (OR) = 1.66, 1.80 and 3.20 for quartiles 2-4, respectively, p-trend = 0.001], diffuse large B-cell lymphoma (DLBCL) (OR = 1.20, 2.48 and 2.36 for quartiles 2-4, respectively, p-trend = 0.03) and follicular lymphoma (FL) (OR = 1.39, 1.90 and 2.69 for quartiles 2-4, respectively, p-trend = 0.02) with increasing TL. This study suggests an association between longer leucocyte TL and increased risk of BCL which was most pronounced for DLBCL and FL.

KW - Lymphoma

KW - NHL

KW - Prospective study

KW - Telomeres

UR - http://www.scopus.com/inward/record.url?scp=84908666631&partnerID=8YFLogxK

U2 - 10.1002/ijc.28934

DO - 10.1002/ijc.28934

M3 - Article

AN - SCOPUS:84908666631

SN - 0020-7136

VL - 135

SP - 2910

EP - 2917

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 12

ER -

Prediagnostic telomere length and risk of B-cell lymphoma-results from the epic cohort study

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