Abstract
1 We investigated whether virus-induced airway hyperresponsiveness in guinea-pigs could be modulated by pretreatment with capsaicin and whether viral respiratory infections could potentiate ovalbumin-aerosol-induced tracheal hyperresponsiveness. 2 Animals were inoculated intratracheaily with bovine parainfluenza-3 virus or control medium 7 days after treatment with capsaicin (50 mg kg-1, s.c.). Four days after inoculation, tracheal contractions were measured to increasing concentrations of substance P, histamine and the cholinoeeptor agonist, arecoline. 3 In tracheae from virus-infected guinea-pigs, contractions in response to substance P, histamine and arecoline were significantly enhanced (P
| Original language | English |
|---|---|
| Pages (from-to) | 1048-1052 |
| Number of pages | 5 |
| Journal | British Journal of Pharmacology |
| Volume | 115 |
| Issue number | 6 |
| Publication status | Published - 28 Mar 1995 |
Keywords
- Airway reactivity
- Capsaicin
- Ovalbumin
- Tracheal hyperresponsiveness
- Virus infection
- arecoline
- capsaicin
- histamine
- ovalbumin
- substance P
- tachykinin
- animal experiment
- article
- bronchus hyperreactivity
- controlled study
- guinea pig
- male
- nonhuman
- Human parainfluenza virus 3
- priority journal
- respiratory tract infection
- sensitization
- smooth muscle contraction
- trachea
- trachea muscle
- virus infection