Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host

W.I. Santema; V.P.M.G. Rutten; R.P.A.M. Segers; J. Poot; S. Hensen; J.A.P. Heesterbeek; A.P. Koets

doi:10.1128/IAI.01121-12

Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host

W.I. Santema, V.P.M.G. Rutten, R.P.A.M. Segers, J. Poot, S. Hensen, J.A.P. Heesterbeek, A.P. Koets

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Abstract

The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.

Original language	English
Pages (from-to)	1990-1995
Number of pages	6
Journal	Infection and Immunity
Volume	81
Issue number	6
DOIs	https://doi.org/10.1128/IAI.01121-12
Publication status	Published - 2013

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title = "Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host",

abstract = "The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.",

author = "W.I. Santema and V.P.M.G. Rutten and R.P.A.M. Segers and J. Poot and S. Hensen and J.A.P. Heesterbeek and A.P. Koets",

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AU - Santema, W.I.

AU - Rutten, V.P.M.G.

AU - Segers, R.P.A.M.

AU - Poot, J.

AU - Hensen, S.

AU - Heesterbeek, J.A.P.

AU - Koets, A.P.

PY - 2013

Y1 - 2013

N2 - The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.

AB - The control of chronic bacterial diseases with high prevalence in areas of endemicity would strongly benefit from availability of postexposure vaccines. The development of these vaccines against mycobacterial infections, such as (para)tuberculosis, is hampered by lack of experience in natural hosts. Paratuberculosis in cattle is both a mycobacterial disease of worldwide importance and a natural host model for mycobacterial infections in general. The present study showed beneficial effects of therapeutic heat shock protein 70 (Hsp70) vaccination in cattle with naturally acquired chronic infection with Mycobacterium avium subsp. paratuberculosis. Vaccination-induced protection was associated with antibody responses, rather than with induction of specific T helper 1 cells. Targeted therapeutic postexposure vaccination complementary to selective use of antibiotics could be an effective approach for control of chronic mycobacterial infections.

U2 - 10.1128/IAI.01121-12

DO - 10.1128/IAI.01121-12

M3 - Article

SN - 0019-9567

VL - 81

SP - 1990

EP - 1995

JO - Infection and Immunity

JF - Infection and Immunity

IS - 6

ER -

Postexposure Subunit Vaccination against Chronic Enteric Mycobacterial Infection in a Natural Host

Abstract

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