Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

M. Shen; R.C.H. Vermeulen; P. Rajaraman; I. Menashe; X. He; R.S. Chapman; M. Yeager; G. Thomas; L. Burdett; A. Hutchinson; J. Yuenger; S. Chanock; Q. Lan

Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

M. Shen, R.C.H. Vermeulen, P. Rajaraman, I. Menashe, X. He, R.S. Chapman, M. Yeager, G. Thomas, L. Burdett, A. Hutchinson, J. Yuenger, S. Chanock, Q. Lan

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The high incidence of lung cancer in Xuanwei County, China has been attributed to exposure to indoor smoky coal emissions that contain polycyclic aromatic hydrocarbons (PAHs). The inflammatory response induced by coal smoke components may promote lung tumor development. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and lung cancer risk in a population-based case-control study (122 cases and 122 controls) in Xuanwei. A total of 1,360 tag SNPs in 149 gene regions were included in the analysis. FCER2 rs7249320 was the most significant SNP (OR: 0.30; 95% CI: 0.16-0.55; P: 0.0001; false discovery rate value, 0.13) for variant carriers. The gene regions ALOX12B/ALOX15B and KLK2 were associated with increased lung cancer risk globally (false discovery rate value

Original language	Undefined/Unknown
Pages (from-to)	285-290
Number of pages	6
Journal	Environmental and Molecular Mutagenesis
Volume	50
Issue number	4
Publication status	Published - 2009

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Cite this

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title = "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.",

abstract = "The high incidence of lung cancer in Xuanwei County, China has been attributed to exposure to indoor smoky coal emissions that contain polycyclic aromatic hydrocarbons (PAHs). The inflammatory response induced by coal smoke components may promote lung tumor development. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and lung cancer risk in a population-based case-control study (122 cases and 122 controls) in Xuanwei. A total of 1,360 tag SNPs in 149 gene regions were included in the analysis. FCER2 rs7249320 was the most significant SNP (OR: 0.30; 95% CI: 0.16-0.55; P: 0.0001; false discovery rate value, 0.13) for variant carriers. The gene regions ALOX12B/ALOX15B and KLK2 were associated with increased lung cancer risk globally (false discovery rate value",

author = "M. Shen and R.C.H. Vermeulen and P. Rajaraman and I. Menashe and X. He and R.S. Chapman and M. Yeager and G. Thomas and L. Burdett and A. Hutchinson and J. Yuenger and S. Chanock and Q. Lan",

year = "2009",

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TY - JOUR

T1 - Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.

AU - Shen, M.

AU - Vermeulen, R.C.H.

AU - Rajaraman, P.

AU - Menashe, I.

AU - He, X.

AU - Chapman, R.S.

AU - Yeager, M.

AU - Thomas, G.

AU - Burdett, L.

AU - Hutchinson, A.

AU - Yuenger, J.

AU - Chanock, S.

AU - Lan, Q.

PY - 2009

Y1 - 2009

N2 - The high incidence of lung cancer in Xuanwei County, China has been attributed to exposure to indoor smoky coal emissions that contain polycyclic aromatic hydrocarbons (PAHs). The inflammatory response induced by coal smoke components may promote lung tumor development. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and lung cancer risk in a population-based case-control study (122 cases and 122 controls) in Xuanwei. A total of 1,360 tag SNPs in 149 gene regions were included in the analysis. FCER2 rs7249320 was the most significant SNP (OR: 0.30; 95% CI: 0.16-0.55; P: 0.0001; false discovery rate value, 0.13) for variant carriers. The gene regions ALOX12B/ALOX15B and KLK2 were associated with increased lung cancer risk globally (false discovery rate value

AB - The high incidence of lung cancer in Xuanwei County, China has been attributed to exposure to indoor smoky coal emissions that contain polycyclic aromatic hydrocarbons (PAHs). The inflammatory response induced by coal smoke components may promote lung tumor development. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and lung cancer risk in a population-based case-control study (122 cases and 122 controls) in Xuanwei. A total of 1,360 tag SNPs in 149 gene regions were included in the analysis. FCER2 rs7249320 was the most significant SNP (OR: 0.30; 95% CI: 0.16-0.55; P: 0.0001; false discovery rate value, 0.13) for variant carriers. The gene regions ALOX12B/ALOX15B and KLK2 were associated with increased lung cancer risk globally (false discovery rate value

M3 - Article

SN - 0893-6692

VL - 50

SP - 285

EP - 290

JO - Environmental and Molecular Mutagenesis

JF - Environmental and Molecular Mutagenesis

IS - 4

ER -