Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

M. Shen; L. Zhang; K.M. Lee; R. Vermeulen; H.D. Hosgood; G. Li; S. Yin; M. Rothman; S. Chanock; M.T. Smith; Q. Lan

doi:10.3858/emm.2011.43.6.041

Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

M. Shen, L. Zhang, K.M. Lee, R. Vermeulen, H.D. Hosgood, G. Li, S. Yin, M. Rothman, S. Chanock, M.T. Smith, Q. Lan

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Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P

Original language	Undefined/Unknown
Pages (from-to)	374-378
Number of pages	5
Journal	Experimental & Molecular Medicine
Volume	43
Issue number	6
DOIs	https://doi.org/10.3858/emm.2011.43.6.041
Publication status	Published - 2011

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10.3858/emm.2011.43.6.041

http://www.ncbi.nlm.nih.gov/pubmed/21540635

Cite this

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title = "Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity",

abstract = "Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P",

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T1 - Polymorphisms in genes involved in innate immunity and susceptibility to benzene-induced hematotoxicity

AU - Shen, M.

AU - Zhang, L.

AU - Lee, K.M.

AU - Vermeulen, R.

AU - Hosgood, H.D.

AU - Li, G.

AU - Yin, S.

AU - Rothman, M.

AU - Chanock, S.

AU - Smith, M.T.

AU - Lan, Q.

PY - 2011

Y1 - 2011

N2 - Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P

AB - Benzene, a recognized hematotoxicant and carcinogen, can damage the human immune system. We studied the association between single nucleotide polymorphisms (SNPs) in genes involved in innate immunity and benzene hematotoxicity in a cross-sectional study of workers exposed to benzene (250 workers and 140 controls). A total of 1,236 tag SNPs in 149 gene regions of six pathways were included in the analysis. Six gene regions were significant for their association with white blood cell (WBC) counts (MBP, VCAM1, ALOX5, MPO, RAC2, and CRP) based on gene-region (P

U2 - 10.3858/emm.2011.43.6.041

DO - 10.3858/emm.2011.43.6.041

M3 - Article

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VL - 43

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JO - Experimental & Molecular Medicine

JF - Experimental & Molecular Medicine

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