Abstract
PEGylation, or the chemical conjugation of polyethylene glycol
(PEG) to an anchor molecule, is frequently employed in nano- and
microparticle drug delivery technology to sterically stabilize the
drug carrier and to confer ‘stealth’ properties. The hydrophilicity of
PEGylated formulations, the repulsive interactions between PEGgrafted
surfaces and blood constituents, and the decreased rate of
protein adsorption on the surface of PEGylated drug carriers
contribute to the evasive properties through which rapid clearance
by cells of the reticuloendothelial system (RES) is considerably
forestalled (Harding et al., 1997; Gabizon and Papahadjopoulos,
1992).
| Original language | Undefined/Unknown |
|---|---|
| Pages (from-to) | 1-3 |
| Number of pages | 3 |
| Journal | Microvascular Research |
| Volume | 78 |
| Issue number | 1 |
| Publication status | Published - 2009 |