Plasticity of Individual Lung Function States from Childhood to Adulthood

Gang Wang; Jenny Hallberg; Rosa Faner; Hans-Jacob Koefoed; Simon Kebede Merid; Susanna Klevebro; Sophia Björkander; Olena Gruzieva; Göran Pershagen; Marianne van Hage; Stefano Guerra; Matteo Bottai; Antonios Georgelis; Ulrike Gehring; Anna Bergström; Judith M Vonk; Inger Kull; Gerard H Koppelman; Alvar Agusti; Erik Melén

doi:10.1164/rccm.202203-0444OC

Plasticity of Individual Lung Function States from Childhood to Adulthood

Gang Wang, Jenny Hallberg, Rosa Faner, Hans-Jacob Koefoed, Simon Kebede Merid, Susanna Klevebro, Sophia Björkander, Olena Gruzieva, Göran Pershagen, Marianne van Hage, Stefano Guerra, Matteo Bottai, Antonios Georgelis, Ulrike Gehring, Anna Bergström, Judith M Vonk, Inger Kull, Gerard H Koppelman, Alvar Agusti, Erik Melén^*

^*Corresponding author for this work

IRAS OH Epidemiology Chemical Agents

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.

OBJECTIVES: To explore the plasticity of individual lung function states during childhood.

METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.

MEASUREMENTS AND MAIN RESULTS: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.

CONCLUSIONS: Individual lung function states during childhood are plastic, including catch-up and growth failure.

Original language	English
Pages (from-to)	406-415
Number of pages	10
Journal	American Journal of Respiratory and Critical Care Medicine
Volume	207
Issue number	4
DOIs	https://doi.org/10.1164/rccm.202203-0444OC
Publication status	Published - 21 Nov 2022

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Wang, G., Hallberg, J., Faner, R., Koefoed, H.-J., Kebede Merid, S., Klevebro, S., Björkander, S., Gruzieva, O., Pershagen, G., van Hage, M., Guerra, S., Bottai, M., Georgelis, A., Gehring, U., Bergström, A., Vonk, J. M., Kull, I., Koppelman, G. H., Agusti, A., & Melén, E. (2022). Plasticity of Individual Lung Function States from Childhood to Adulthood. American Journal of Respiratory and Critical Care Medicine, 207(4), 406-415. https://doi.org/10.1164/rccm.202203-0444OC

@article{1bd47991d8c04d0e80952014c76eb9bd,

title = "Plasticity of Individual Lung Function States from Childhood to Adulthood",

abstract = "RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.OBJECTIVES: To explore the plasticity of individual lung function states during childhood.METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.MEASUREMENTS AND MAIN RESULTS: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5\%) BAMSE participants with low/very low states and 36 (2.4\%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.CONCLUSIONS: Individual lung function states during childhood are plastic, including catch-up and growth failure.",

author = "Gang Wang and Jenny Hallberg and Rosa Faner and Hans-Jacob Koefoed and \{Kebede Merid\}, Simon and Susanna Klevebro and Sophia Bj{\"o}rkander and Olena Gruzieva and G{\"o}ran Pershagen and \{van Hage\}, Marianne and Stefano Guerra and Matteo Bottai and Antonios Georgelis and Ulrike Gehring and Anna Bergstr{\"o}m and Vonk, \{Judith M\} and Inger Kull and Koppelman, \{Gerard H\} and Alvar Agusti and Erik Mel{\'e}n",

year = "2022",

month = nov,

day = "21",

doi = "10.1164/rccm.202203-0444OC",

language = "English",

volume = "207",

pages = "406--415",

journal = "American Journal of Respiratory and Critical Care Medicine",

issn = "1073-449X",

publisher = "American Thoracic Society",

number = "4",

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Wang, G, Hallberg, J, Faner, R, Koefoed, H-J, Kebede Merid, S, Klevebro, S, Björkander, S, Gruzieva, O, Pershagen, G, van Hage, M, Guerra, S, Bottai, M, Georgelis, A, Gehring, U, Bergström, A, Vonk, JM, Kull, I, Koppelman, GH, Agusti, A & Melén, E 2022, 'Plasticity of Individual Lung Function States from Childhood to Adulthood', American Journal of Respiratory and Critical Care Medicine, vol. 207, no. 4, pp. 406-415. https://doi.org/10.1164/rccm.202203-0444OC

TY - JOUR

T1 - Plasticity of Individual Lung Function States from Childhood to Adulthood

AU - Wang, Gang

AU - Hallberg, Jenny

AU - Faner, Rosa

AU - Koefoed, Hans-Jacob

AU - Kebede Merid, Simon

AU - Klevebro, Susanna

AU - Björkander, Sophia

AU - Gruzieva, Olena

AU - Pershagen, Göran

AU - van Hage, Marianne

AU - Guerra, Stefano

AU - Bottai, Matteo

AU - Georgelis, Antonios

AU - Gehring, Ulrike

AU - Bergström, Anna

AU - Vonk, Judith M

AU - Kull, Inger

AU - Koppelman, Gerard H

AU - Agusti, Alvar

AU - Melén, Erik

PY - 2022/11/21

Y1 - 2022/11/21

N2 - RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.OBJECTIVES: To explore the plasticity of individual lung function states during childhood.METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.MEASUREMENTS AND MAIN RESULTS: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.CONCLUSIONS: Individual lung function states during childhood are plastic, including catch-up and growth failure.

AB - RATIONALE: Recent evidence highlights the importance of optimal lung development during childhood for health throughout life.OBJECTIVES: To explore the plasticity of individual lung function states during childhood.METHODS: Pre-bronchodilator FEV1 z-scores determined at age 8, 16 and 24 years in the Swedish population-based birth cohort BAMSE (N=3,069) were used. An unbiased, data-driven dependent mixture model was applied to explore lung function states and individual state chains. Lung function catch-up was defined as participants moving from low/very low states to normal/high/very high states, and growth failure as moving from normal/high/very high states to low/very low states. At 24 years, we compared respiratory symptoms, small airway function (multiple-breath washout), and circulating inflammatory protein levels, by using proteomics, across states. Models were replicated in the independent Dutch population-based PIAMA cohort.MEASUREMENTS AND MAIN RESULTS: Five lung function states were identified in BAMSE. Lung function catch-up and growth failure were observed in 74 (14.5%) BAMSE participants with low/very low states and 36 (2.4%) participants with normal/high/very high states, respectively. The occurrence of catch-up and growth failure was replicated in PIAMA. Early-life risk factors were cumulatively associated with the very low state, as well as with catch-up (inverse association) and growth failure. The very low state as well as growth failure were associated with respiratory symptoms, airflow limitation, and small airway dysfunction at adulthood. Proteomics identified Interleukin-6 and C-X-C motif chemokine 10 as potential biomarkers of impaired lung function development.CONCLUSIONS: Individual lung function states during childhood are plastic, including catch-up and growth failure.

U2 - 10.1164/rccm.202203-0444OC

DO - 10.1164/rccm.202203-0444OC

M3 - Article

C2 - 36409973

SN - 1073-449X

VL - 207

SP - 406

EP - 415

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

IS - 4

ER -

Plasticity of Individual Lung Function States from Childhood to Adulthood

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