Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition.

A. Luczynska; R. Kaaks; S. Rohrmann; S. Becker; J. Linseisen; B. Buijsse; K. Overvad; A. Trichopoulou; E. Valanou; A. Barmpitsioti; G. Masala; C. Agnoli; R. Tumino; S. Panico; H.B. Bueno de Mesquita; F.J. van Duijnhoven; P.H.M. Peeters; R. Vermeulen; E. Weiderpass; M. Brustad; G. Skeie; C.A. Gonzalez; P. Jakszyn; J.R. Quiros; M.J. Sanchez; J.M. Huerta; E. Ardanaz; B. Melin; A.S. Johansson; M. Almquist; J. Malm; K.T. Khaw; N. Wareham; R.C. Travis; V. Fedirko; I. Romieu; M. Jenab; V. Gallo; E. Riboli; P. Vineis; A. Nieters

doi:10.3945/ajcn.112.054676

Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition.

A. Luczynska, R. Kaaks, S. Rohrmann, S. Becker, J. Linseisen, B. Buijsse, K. Overvad, A. Trichopoulou, E. Valanou, A. Barmpitsioti, G. Masala, C. Agnoli, R. Tumino, S. Panico, H.B. Bueno de Mesquita, F.J. van Duijnhoven, P.H.M. Peeters, R. Vermeulen, E. Weiderpass, M. BrustadG. Skeie, C.A. Gonzalez, P. Jakszyn, J.R. Quiros, M.J. Sanchez, J.M. Huerta, E. Ardanaz, B. Melin, A.S. Johansson, M. Almquist, J. Malm, K.T. Khaw, N. Wareham, R.C. Travis, V. Fedirko, I. Romieu, M. Jenab, V. Gallo, E. Riboli, P. Vineis, A. Nieters

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: The relation between vitamin D status and lymphoma risk is inconclusive. OBJECTIVE: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. DESIGN: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. RESULTS: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >/=2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). CONCLUSIONS: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

Original language	Undefined/Unknown
Pages (from-to)	827-38
Number of pages	12
Journal	American Journal of Clinical Nutrition
Volume	98
Issue number	3
DOIs	https://doi.org/10.3945/ajcn.112.054676
Publication status	Published - 2013

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Luczynska, A., Kaaks, R., Rohrmann, S., Becker, S., Linseisen, J., Buijsse, B., Overvad, K., Trichopoulou, A., Valanou, E., Barmpitsioti, A., Masala, G., Agnoli, C., Tumino, R., Panico, S., Bueno de Mesquita, H. B., van Duijnhoven, F. J., Peeters, P. H. M., Vermeulen, R., Weiderpass, E., ... Nieters, A. (2013). Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition, 98(3), 827-38. https://doi.org/10.3945/ajcn.112.054676

@article{30a62798c9c7432a8d2f7cf318e80989,

title = "Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition.",

abstract = "BACKGROUND: The relation between vitamin D status and lymphoma risk is inconclusive. OBJECTIVE: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. DESIGN: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. RESULTS: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >/=2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). CONCLUSIONS: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.",

author = "A. Luczynska and R. Kaaks and S. Rohrmann and S. Becker and J. Linseisen and B. Buijsse and K. Overvad and A. Trichopoulou and E. Valanou and A. Barmpitsioti and G. Masala and C. Agnoli and R. Tumino and S. Panico and {Bueno de Mesquita}, H.B. and {van Duijnhoven}, F.J. and P.H.M. Peeters and R. Vermeulen and E. Weiderpass and M. Brustad and G. Skeie and C.A. Gonzalez and P. Jakszyn and J.R. Quiros and M.J. Sanchez and J.M. Huerta and E. Ardanaz and B. Melin and A.S. Johansson and M. Almquist and J. Malm and K.T. Khaw and N. Wareham and R.C. Travis and V. Fedirko and I. Romieu and M. Jenab and V. Gallo and E. Riboli and P. Vineis and A. Nieters",

year = "2013",

doi = "10.3945/ajcn.112.054676",

language = "Undefined/Unknown",

volume = "98",

pages = "827--38",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier BV",

number = "3",

}

Luczynska, A, Kaaks, R, Rohrmann, S, Becker, S, Linseisen, J, Buijsse, B, Overvad, K, Trichopoulou, A, Valanou, E, Barmpitsioti, A, Masala, G, Agnoli, C, Tumino, R, Panico, S, Bueno de Mesquita, HB, van Duijnhoven, FJ, Peeters, PHM, Vermeulen, R, Weiderpass, E, Brustad, M, Skeie, G, Gonzalez, CA, Jakszyn, P, Quiros, JR, Sanchez, MJ, Huerta, JM, Ardanaz, E, Melin, B, Johansson, AS, Almquist, M, Malm, J, Khaw, KT, Wareham, N, Travis, RC, Fedirko, V, Romieu, I, Jenab, M, Gallo, V, Riboli, E, Vineis, P & Nieters, A 2013, 'Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition.', American Journal of Clinical Nutrition, vol. 98, no. 3, pp. 827-38. https://doi.org/10.3945/ajcn.112.054676

TY - JOUR

T1 - Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition.

AU - Luczynska, A.

AU - Kaaks, R.

AU - Rohrmann, S.

AU - Becker, S.

AU - Linseisen, J.

AU - Buijsse, B.

AU - Overvad, K.

AU - Trichopoulou, A.

AU - Valanou, E.

AU - Barmpitsioti, A.

AU - Masala, G.

AU - Agnoli, C.

AU - Tumino, R.

AU - Panico, S.

AU - Bueno de Mesquita, H.B.

AU - van Duijnhoven, F.J.

AU - Peeters, P.H.M.

AU - Vermeulen, R.

AU - Weiderpass, E.

AU - Brustad, M.

AU - Skeie, G.

AU - Gonzalez, C.A.

AU - Jakszyn, P.

AU - Quiros, J.R.

AU - Sanchez, M.J.

AU - Huerta, J.M.

AU - Ardanaz, E.

AU - Melin, B.

AU - Johansson, A.S.

AU - Almquist, M.

AU - Malm, J.

AU - Khaw, K.T.

AU - Wareham, N.

AU - Travis, R.C.

AU - Fedirko, V.

AU - Romieu, I.

AU - Jenab, M.

AU - Gallo, V.

AU - Riboli, E.

AU - Vineis, P.

AU - Nieters, A.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The relation between vitamin D status and lymphoma risk is inconclusive. OBJECTIVE: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. DESIGN: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. RESULTS: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >/=2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). CONCLUSIONS: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

AB - BACKGROUND: The relation between vitamin D status and lymphoma risk is inconclusive. OBJECTIVE: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. DESIGN: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. RESULTS: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >/=2 y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). CONCLUSIONS: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.

U2 - 10.3945/ajcn.112.054676

DO - 10.3945/ajcn.112.054676

M3 - Article

SN - 0002-9165

VL - 98

SP - 827

EP - 838

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 3

ER -