Physicochemical characterization of degradable thermosensitive polymeric micelles

Osamu Soga; Cornelus F. Van Nostrum; Aissa Ramzi; Tom Visser; Fouad Soulimani; Peter M. Frederik; Paul H.H. Bomans; Wim E. Hennink

doi:10.1021/la048354h

Physicochemical characterization of degradable thermosensitive polymeric micelles

Osamu Soga
, Cornelus F. Van Nostrum
, Aissa Ramzi
, Tom Visser
, Fouad Soulimani
, Peter M. Frederik
, Paul H.H. Bomans
, Wim E. Hennink^*

^*Corresponding author for this work

Utrecht University
Maastricht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The physicochemical characterization of degradable thermosensitive polymeric micelles was presented. Dynamic light scattering measurements showed that these block copolymers form polymeric micelles in water with a size of 50 nm by heating of an aqueous polymer solution. Fluorescence spectroscopy measurements with pyrene loaded in the hydrophobic core of the micelles showed that these micelles were incubated at pH 8.6. It was found that the micelles possess a spherical shape with a narrow size distribution.

Original language	English
Pages (from-to)	9388-9395
Number of pages	8
Journal	Langmuir
Volume	20
Issue number	21
DOIs	https://doi.org/10.1021/la048354h
Publication status	Published - 12 Oct 2004

Keywords

Farmacie/Biofarmaceutische wetenschappen (FARM)
Medical technology
Farmacie(FARM)
Biomedische technologie en medicijnen
Pharmacology

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10.1021/la048354h

frederik-et-al-2004-physicochemical-characterization-of-degradable-thermosensitive-polymeric-micellesFinal published version, 200 KBLicence: Taverne

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title = "Physicochemical characterization of degradable thermosensitive polymeric micelles",

abstract = "The physicochemical characterization of degradable thermosensitive polymeric micelles was presented. Dynamic light scattering measurements showed that these block copolymers form polymeric micelles in water with a size of 50 nm by heating of an aqueous polymer solution. Fluorescence spectroscopy measurements with pyrene loaded in the hydrophobic core of the micelles showed that these micelles were incubated at pH 8.6. It was found that the micelles possess a spherical shape with a narrow size distribution.",

keywords = "Farmacie/Biofarmaceutische wetenschappen (FARM), Medical technology, Farmacie(FARM), Biomedische technologie en medicijnen, Pharmacology",

author = "Osamu Soga and \{Van Nostrum\}, \{Cornelus F.\} and Aissa Ramzi and Tom Visser and Fouad Soulimani and Frederik, \{Peter M.\} and Bomans, \{Paul H.H.\} and Hennink, \{Wim E.\}",

year = "2004",

month = oct,

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doi = "10.1021/la048354h",

language = "English",

volume = "20",

pages = "9388--9395",

journal = "Langmuir",

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T1 - Physicochemical characterization of degradable thermosensitive polymeric micelles

AU - Soga, Osamu

AU - Van Nostrum, Cornelus F.

AU - Ramzi, Aissa

AU - Visser, Tom

AU - Soulimani, Fouad

AU - Frederik, Peter M.

AU - Bomans, Paul H.H.

AU - Hennink, Wim E.

PY - 2004/10/12

Y1 - 2004/10/12

N2 - The physicochemical characterization of degradable thermosensitive polymeric micelles was presented. Dynamic light scattering measurements showed that these block copolymers form polymeric micelles in water with a size of 50 nm by heating of an aqueous polymer solution. Fluorescence spectroscopy measurements with pyrene loaded in the hydrophobic core of the micelles showed that these micelles were incubated at pH 8.6. It was found that the micelles possess a spherical shape with a narrow size distribution.

AB - The physicochemical characterization of degradable thermosensitive polymeric micelles was presented. Dynamic light scattering measurements showed that these block copolymers form polymeric micelles in water with a size of 50 nm by heating of an aqueous polymer solution. Fluorescence spectroscopy measurements with pyrene loaded in the hydrophobic core of the micelles showed that these micelles were incubated at pH 8.6. It was found that the micelles possess a spherical shape with a narrow size distribution.

KW - Farmacie/Biofarmaceutische wetenschappen (FARM)

KW - Medical technology

KW - Farmacie(FARM)

KW - Biomedische technologie en medicijnen

KW - Pharmacology

UR - https://www.scopus.com/pages/publications/6444232811

U2 - 10.1021/la048354h

DO - 10.1021/la048354h

M3 - Article

C2 - 15461534

SN - 0743-7463

VL - 20

SP - 9388

EP - 9395

JO - Langmuir

JF - Langmuir

IS - 21

ER -

Physicochemical characterization of degradable thermosensitive polymeric micelles

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