Pheochromocytomas and paragangliomas in humans and dogs

S. Galac, E Korpershoek

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    Pheochromocytomas (PCCs) and paragangliomas (PGLs) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Surgery is curative when PCC and PGL have not metastasized, while only palliative treatment is possible for patients with metastatic disease. Mutations in succinate dehydrogenase subunit B (SDHB) are associated with metastatic behaviour in human PCC/PGL and the same mutation has been described in dogs. The dog might therefore be a suitable model for study of the pathogenesis of metastatic PCC and PGL in humans. Further molecular studies of common tumourigenic pathways and comparative studies of histopathology of human and canine PCC and PGL are warranted.
    Original languageEnglish
    Pages (from-to)1158-1170
    Number of pages13
    JournalVeterinary and Comparative Oncology
    Volume15
    Issue number4
    DOIs
    Publication statusPublished - 1 Dec 2017

    Keywords

    • animal model
    • diagnosis
    • paraganglioma
    • pathology
    • pheochromocytoma

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