Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

M. Wadelius; S. E. Marshall; G. Islander; L. Nordang; M. Karawajczyk; Q. Y. Yue; I. Terreehorst; E. V. Baranova; S. Hugosson; K. Sköldefors; M. Pirmohamed; A. H. Maitland-van der Zee; A. Alfirevic; P. Hallberg; C. N A Palmer

doi:10.1038/clpt.2014.138

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

M. Wadelius, S. E. Marshall, G. Islander, L. Nordang, M. Karawajczyk, Q. Y. Yue, I. Terreehorst, E. V. Baranova, S. Hugosson, K. Sköldefors, M. Pirmohamed, A. H. Maitland-van der Zee, A. Alfirevic, P. Hallberg, C. N A Palmer

Pharmacoepidemiology and Clinical Pharmacology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.Clinical Pharmacology & Therapeutics (2014); advance online publication 13 August 2014. doi:10.1038/clpt.2014.138.

Original language	English
Pages (from-to)	477-481
Journal	Clinical Pharmacology and Therapeutics
Volume	96
Issue number	4
DOIs	https://doi.org/10.1038/clpt.2014.138
Publication status	Published - Oct 2014

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Clin Pharma and Therapeutics - 2014 - Wadelius - Phenotype Standardization of Angioedema in the Head and Neck Region CausedFinal published version, 394 KBLicence: CC BY-NC-ND

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Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. Y., Terreehorst, I., Baranova, E. V., Hugosson, S., Sköldefors, K., Pirmohamed, M., Maitland-van der Zee, A. H., Alfirevic, A., Hallberg, P., & Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. Clinical Pharmacology and Therapeutics, 96(4), 477-481. https://doi.org/10.1038/clpt.2014.138

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title = "Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System",

abstract = "Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.Clinical Pharmacology & Therapeutics (2014); advance online publication 13 August 2014. doi:10.1038/clpt.2014.138.",

author = "M. Wadelius and Marshall, {S. E.} and G. Islander and L. Nordang and M. Karawajczyk and Yue, {Q. Y.} and I. Terreehorst and Baranova, {E. V.} and S. Hugosson and K. Sk{\"o}ldefors and M. Pirmohamed and {Maitland-van der Zee}, {A. H.} and A. Alfirevic and P. Hallberg and Palmer, {C. N A}",

year = "2014",

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doi = "10.1038/clpt.2014.138",

language = "English",

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Wadelius, M, Marshall, SE, Islander, G, Nordang, L, Karawajczyk, M, Yue, QY, Terreehorst, I, Baranova, EV, Hugosson, S, Sköldefors, K, Pirmohamed, M, Maitland-van der Zee, AH, Alfirevic, A, Hallberg, P & Palmer, CNA 2014, 'Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System', Clinical Pharmacology and Therapeutics, vol. 96, no. 4, pp. 477-481. https://doi.org/10.1038/clpt.2014.138

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T1 - Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

AU - Wadelius, M.

AU - Marshall, S. E.

AU - Islander, G.

AU - Nordang, L.

AU - Karawajczyk, M.

AU - Yue, Q. Y.

AU - Terreehorst, I.

AU - Baranova, E. V.

AU - Hugosson, S.

AU - Sköldefors, K.

AU - Pirmohamed, M.

AU - Maitland-van der Zee, A. H.

AU - Alfirevic, A.

AU - Hallberg, P.

AU - Palmer, C. N A

PY - 2014/10

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AB - Angioedema is a potentially life-threatening adverse reaction to angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. To study the genetic etiology of this rare adverse event, international consortia and multicenter recruitment of patients are needed. To reduce patient heterogeneity, we have standardized the phenotype. In brief, it comprises swelling in the head and neck region that first occurs during treatment. It should not coincide with urticaria or have another likely cause such as hereditary angioedema.Clinical Pharmacology & Therapeutics (2014); advance online publication 13 August 2014. doi:10.1038/clpt.2014.138.

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DO - 10.1038/clpt.2014.138

M3 - Article

SN - 0009-9236

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JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

IS - 4

ER -

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System

Abstract

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