Pharmacokinetics of the KRAS G12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c.

Nancy H C Loos, Irene A Retmana, Jamie Rijmers, Yaogeng Wang, Changpei Gan, Maria C Lebre, Rolf W Sparidans, Jos H Beijnen, Alfred H Schinkel

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Pharmacology, Toxicology and Pharmaceutical Science