Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

Corine de Jong, Stefan Sanders, Geert-Jan Creemers, Artur M Burylo, Margot Taks, Jan H M Schellens, Maarten J Deenen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.

Original languageEnglish
Pages (from-to)2120-2122
Number of pages3
JournalBritish Journal of Clinical Pharmacology
Volume83
Issue number9
DOIs
Publication statusPublished - Sept 2017

Keywords

  • cisplatin
  • genotyping
  • nephrotoxicity
  • pharmacogenomics
  • case reports

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