Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

Corine de Jong; Stefan Sanders; Geert-Jan Creemers; Artur M Burylo; Margot Taks; Jan H M Schellens; Maarten J Deenen

doi:10.1111/bcp.13309

Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

Corine de Jong, Stefan Sanders, Geert-Jan Creemers, Artur M Burylo, Margot Taks, Jan H M Schellens, Maarten J Deenen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.

Original language	English
Pages (from-to)	2120-2122
Number of pages	3
Journal	British Journal of Clinical Pharmacology
Volume	83
Issue number	9
DOIs	https://doi.org/10.1111/bcp.13309
Publication status	Published - Sept 2017

Keywords

cisplatin
genotyping
nephrotoxicity
pharmacogenomics
case reports

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10.1111/bcp.13309

PharmacogeneticFinal published version, 162 KBLicence: Taverne

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title = "Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman",

abstract = "In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.",

keywords = "cisplatin, genotyping, nephrotoxicity, pharmacogenomics, case reports",

author = "{de Jong}, Corine and Stefan Sanders and Geert-Jan Creemers and Burylo, {Artur M} and Margot Taks and Schellens, {Jan H M} and Deenen, {Maarten J}",

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doi = "10.1111/bcp.13309",

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T1 - Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy

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AU - de Jong, Corine

AU - Sanders, Stefan

AU - Creemers, Geert-Jan

AU - Burylo, Artur M

AU - Taks, Margot

AU - Schellens, Jan H M

AU - Deenen, Maarten J

PY - 2017/9

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AB - In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.

KW - cisplatin

KW - genotyping

KW - nephrotoxicity

KW - pharmacogenomics

KW - case reports

U2 - 10.1111/bcp.13309

DO - 10.1111/bcp.13309

M3 - Article

C2 - 28560854

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VL - 83

SP - 2120

EP - 2122

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 9

ER -

Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman

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