Perseveration induces dissociative uncertainty in obsessive-compulsive disorder

Background and Objectives
Obsessive compulsive (OC)-like perseveration paradoxically increases feelings of uncertainty. We studied whether the underlying mechanism between perseveration and uncertainty is a reduced accessibility of meaning (‘semantic satiation’).

Methods
OCD patients (n = 24) and matched non-clinical controls (n = 24) repeated words 2 (non-perseveration) or 20 times (perseveration). They decided whether this word was related to another target word. Speed of relatedness judgments and feelings of dissociative uncertainty were measured. The effects of real-life perseveration on dissociative uncertainty were tested in a smaller subsample of the OCD group (n = 9).

Results
Speed of relatedness judgments was not affected by perseveration. However, both groups reported more dissociative uncertainty after perseveration compared to non-perseveration, which was higher in OCD patients. Patients reported more dissociative uncertainty after ‘clinical’ perseveration compared to non-perseveration.

Limitations
Both parts of this study are limited by some methodological issues and a small sample size.

Conclusions
Although the mechanism behind ‘perseveration → uncertainty’ is still unclear, results suggest that the effects of perseveration are counterproductive.