Peripheral panic symptoms occur during changes in alveolar carbon dioxide

Marcel A. van den Hout*, Eric Griez

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

On the consideration that single inhalation of a 35% CO2 65% O2 mixture produces symptoms comparable to those observed during hyperventilation, lactate infusion or natural panic attacks, the following were investigated: (1) what changes in PACO2 take place after such inhalation and (2) if and how these are related to the occurrence of (peripheral) panic symptoms. Single CO2 O2 intake resulted in an immediate alveolar hypercapnia, a strong and sudden PACO2 drop after exhalation of the mixture, followed by a hypocapnic overshoot. The findings indicated that occurrence of (peripheral) panic symptoms should neither be attributed to the immediate hypercapnia, nor to the hypocapnic overshoot, but to the sudden drops in PACO2.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalComprehensive Psychiatry
Volume26
Issue number4
DOIs
Publication statusPublished - 1 Jan 1985
Externally publishedYes

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