PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

B. Zoetebier; A. Sohrabi; B. Lou; M. A. Hempenius; W. E. Hennink; G. J. Vancso

doi:10.1039/c6cc02733d

PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

B. Zoetebier
, A. Sohrabi
, B. Lou
, M. A. Hempenius
, W. E. Hennink^*
, G. J. Vancso

^*Corresponding author for this work

University of Twente
University of California Office of the President
External unknown

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

Original language	English
Pages (from-to)	7707-7710
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	49
DOIs	https://doi.org/10.1039/c6cc02733d
Publication status	Published - 2016

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10.1039/c6cc02733d

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title = "PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery",

abstract = "Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.",

author = "B. Zoetebier and A. Sohrabi and B. Lou and Hempenius, \{M. A.\} and Hennink, \{W. E.\} and Vancso, \{G. J.\}",

year = "2016",

doi = "10.1039/c6cc02733d",

language = "English",

volume = "52",

pages = "7707--7710",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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T1 - PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

AU - Zoetebier, B.

AU - Sohrabi, A.

AU - Lou, B.

AU - Hempenius, M. A.

AU - Hennink, W. E.

AU - Vancso, G. J.

PY - 2016

Y1 - 2016

N2 - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

AB - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

UR - https://www.scopus.com/pages/publications/84974560087

U2 - 10.1039/c6cc02733d

DO - 10.1039/c6cc02733d

M3 - Article

AN - SCOPUS:84974560087

SN - 1359-7345

VL - 52

SP - 7707

EP - 7710

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

Abstract

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