PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

B. Zoetebier; A. Sohrabi; B. Lou; M. A. Hempenius; W. E. Hennink; G. J. Vancso

doi:10.1039/c6cc02733d

PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

B. Zoetebier, A. Sohrabi, B. Lou, M. A. Hempenius, W. E. Hennink^*, G. J. Vancso

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

Original language	English
Pages (from-to)	7707-7710
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	49
DOIs	https://doi.org/10.1039/c6cc02733d
Publication status	Published - 2016

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10.1039/c6cc02733d

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title = "PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery",

abstract = "Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.",

author = "B. Zoetebier and A. Sohrabi and B. Lou and Hempenius, {M. A.} and Hennink, {W. E.} and Vancso, {G. J.}",

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T1 - PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

AU - Zoetebier, B.

AU - Sohrabi, A.

AU - Lou, B.

AU - Hempenius, M. A.

AU - Hennink, W. E.

AU - Vancso, G. J.

PY - 2016

Y1 - 2016

N2 - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

AB - Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.

UR - http://www.scopus.com/inward/record.url?scp=84974560087&partnerID=8YFLogxK

U2 - 10.1039/c6cc02733d

DO - 10.1039/c6cc02733d

M3 - Article

AN - SCOPUS:84974560087

SN - 1359-7345

VL - 52

SP - 7707

EP - 7710

JO - Chemical Communications

JF - Chemical Communications

IS - 49

ER -

PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

Abstract

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