Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Caroline G. M. de Theije; Jiangbo Wu; Sofia Lopes da Silva; Patrick J. Kamphuis; Johan Garssen; S. Mechiel Korte; Aletta D. Kraneveld

doi:10.1016/j.ejphar.2011.07.013

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Caroline G. M. de Theije^*, Jiangbo Wu, Sofia Lopes da Silva, Patrick J. Kamphuis, Johan Garssen, S. Mechiel Korte, Aletta D. Kraneveld

^*Corresponding author for this work

Pharmacology

Utrecht University

Research output: Contribution to journal › Literature review › peer-review

Abstract

Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy. (C) 2011 Published by Elsevier B.V.

Original language	English
Pages (from-to)	S70-S80
Number of pages	11
Journal	European Journal of Pharmacology
Volume	668
DOIs	https://doi.org/10.1016/j.ejphar.2011.07.013
Publication status	Published - Sept 2011

Keywords

Autism spectrum disorder
Gastrointestinal disturbances
Neuroimmune interactions
Gut-brain axis
INFLAMMATORY-BOWEL-DISEASE
NECROSIS-FACTOR-ALPHA
MICROVASCULAR ENDOTHELIAL-CELLS
POLYUNSATURATED FATTY-ACIDS
WHOLE-BLOOD SEROTONIN
GASTROINTESTINAL SYMPTOMS
ALTERNATIVE MEDICINE
MAST-CELLS
5-HYDROXYINDOLEACETIC ACID
DIETARY INTERVENTION

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title = "Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management",

abstract = "Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy. (C) 2011 Published by Elsevier B.V.",

keywords = "Autism spectrum disorder, Gastrointestinal disturbances, Neuroimmune interactions, Gut-brain axis, INFLAMMATORY-BOWEL-DISEASE, NECROSIS-FACTOR-ALPHA, MICROVASCULAR ENDOTHELIAL-CELLS, POLYUNSATURATED FATTY-ACIDS, WHOLE-BLOOD SEROTONIN, GASTROINTESTINAL SYMPTOMS, ALTERNATIVE MEDICINE, MAST-CELLS, 5-HYDROXYINDOLEACETIC ACID, DIETARY INTERVENTION",

author = "{de Theije}, {Caroline G. M.} and Jiangbo Wu and {da Silva}, {Sofia Lopes} and Kamphuis, {Patrick J.} and Johan Garssen and Korte, {S. Mechiel} and Kraneveld, {Aletta D.}",

year = "2011",

month = sep,

doi = "10.1016/j.ejphar.2011.07.013",

language = "English",

volume = "668",

pages = "S70--S80",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

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TY - JOUR

T1 - Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

AU - de Theije, Caroline G. M.

AU - Wu, Jiangbo

AU - da Silva, Sofia Lopes

AU - Kamphuis, Patrick J.

AU - Garssen, Johan

AU - Korte, S. Mechiel

AU - Kraneveld, Aletta D.

PY - 2011/9

Y1 - 2011/9

N2 - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy. (C) 2011 Published by Elsevier B.V.

AB - Autism spectrum disorders (ASDs) are pervasive neurodevelopmental disorders, characterized by impairments in social interaction and communication and the presence of limited, repetitive and stereotyped interests and behavior. Bowel symptoms are frequently reported in children with ASD and a potential role for gastrointestinal disturbances in ASD has been suggested. This review focuses on the importance of (allergic) gastrointestinal problems in ASD. We provide an overview of the possible gut-to-brain pathways and discuss opportunities for pharmaceutical and/or nutritional approaches for therapy. (C) 2011 Published by Elsevier B.V.

KW - Autism spectrum disorder

KW - Gastrointestinal disturbances

KW - Neuroimmune interactions

KW - Gut-brain axis

KW - INFLAMMATORY-BOWEL-DISEASE

KW - NECROSIS-FACTOR-ALPHA

KW - MICROVASCULAR ENDOTHELIAL-CELLS

KW - POLYUNSATURATED FATTY-ACIDS

KW - WHOLE-BLOOD SEROTONIN

KW - GASTROINTESTINAL SYMPTOMS

KW - ALTERNATIVE MEDICINE

KW - MAST-CELLS

KW - 5-HYDROXYINDOLEACETIC ACID

KW - DIETARY INTERVENTION

U2 - 10.1016/j.ejphar.2011.07.013

DO - 10.1016/j.ejphar.2011.07.013

M3 - Literature review

SN - 0014-2999

VL - 668

SP - S70-S80

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

ER -

Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management

Abstract

Keywords

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