Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets

Vincent J Munster; Emmie de Wit; Judith M A van den Brand; Sander Herfst; Eefje J A Schrauwen; Theo M Bestebroer; David A M C van de Vijver; Charles A B Boucher; Marion P G Koopmans; Guus F Rimmelzwaan; Thijs Kuiken; Albert D M E Osterhaus; Ron A M Fouchier

doi:10.1126/science.1177127

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets

Vincent J Munster, Emmie de Wit, Judith M A van den Brand, Sander Herfst, Eefje J A Schrauwen, Theo M Bestebroer, David A M C van de Vijver, Charles A B Boucher, Marion P G Koopmans, Guus F Rimmelzwaan, Thijs Kuiken, Albert D M E Osterhaus, Ron A M Fouchier

National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

Original language	English
Pages (from-to)	481-3
Number of pages	3
Journal	Science
Volume	325
Issue number	5939
DOIs	https://doi.org/10.1126/science.1177127
Publication status	Published - 24 Jul 2009

Keywords

Animals
Bronchi
Child, Preschool
Disease Models, Animal
Female
Ferrets
Humans
Influenza A Virus, H1N1 Subtype
Influenza, Human
Orthomyxoviridae Infections
Respiratory System
Seasons
Swine
Trachea
Virus Replication
Virus Shedding
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1177127

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Munster, V. J., de Wit, E., van den Brand, J. M. A., Herfst, S., Schrauwen, E. J. A., Bestebroer, T. M., van de Vijver, D. A. M. C., Boucher, C. A. B., Koopmans, M. P. G., Rimmelzwaan, G. F., Kuiken, T., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2009). Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets. Science, 325(5939), 481-3. https://doi.org/10.1126/science.1177127

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title = "Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets",

abstract = "The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.",

keywords = "Animals, Bronchi, Child, Preschool, Disease Models, Animal, Female, Ferrets, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Orthomyxoviridae Infections, Respiratory System, Seasons, Swine, Trachea, Virus Replication, Virus Shedding, Journal Article, Research Support, N.I.H., Extramural",

author = "Munster, {Vincent J} and {de Wit}, Emmie and {van den Brand}, {Judith M A} and Sander Herfst and Schrauwen, {Eefje J A} and Bestebroer, {Theo M} and {van de Vijver}, {David A M C} and Boucher, {Charles A B} and Koopmans, {Marion P G} and Rimmelzwaan, {Guus F} and Thijs Kuiken and Osterhaus, {Albert D M E} and Fouchier, {Ron A M}",

year = "2009",

month = jul,

day = "24",

doi = "10.1126/science.1177127",

language = "English",

volume = "325",

pages = "481--3",

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Munster, VJ, de Wit, E, van den Brand, JMA, Herfst, S, Schrauwen, EJA, Bestebroer, TM, van de Vijver, DAMC, Boucher, CAB, Koopmans, MPG, Rimmelzwaan, GF, Kuiken, T, Osterhaus, ADME & Fouchier, RAM 2009, 'Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets', Science, vol. 325, no. 5939, pp. 481-3. https://doi.org/10.1126/science.1177127

TY - JOUR

T1 - Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets

AU - Munster, Vincent J

AU - de Wit, Emmie

AU - van den Brand, Judith M A

AU - Herfst, Sander

AU - Schrauwen, Eefje J A

AU - Bestebroer, Theo M

AU - van de Vijver, David A M C

AU - Boucher, Charles A B

AU - Koopmans, Marion P G

AU - Rimmelzwaan, Guus F

AU - Kuiken, Thijs

AU - Osterhaus, Albert D M E

AU - Fouchier, Ron A M

PY - 2009/7/24

Y1 - 2009/7/24

N2 - The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

AB - The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.

KW - Animals

KW - Bronchi

KW - Child, Preschool

KW - Disease Models, Animal

KW - Female

KW - Ferrets

KW - Humans

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza, Human

KW - Orthomyxoviridae Infections

KW - Respiratory System

KW - Seasons

KW - Swine

KW - Trachea

KW - Virus Replication

KW - Virus Shedding

KW - Journal Article

KW - Research Support, N.I.H., Extramural

U2 - 10.1126/science.1177127

DO - 10.1126/science.1177127

M3 - Article

C2 - 19574348

SN - 0036-8075

VL - 325

SP - 481

EP - 483

JO - Science

JF - Science

IS - 5939

ER -

Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets

Abstract

Keywords

UN SDGs

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