Pathogenesis and pharmacotherapy of Hidradenitis suppurativa

Maiwand Nazary, H.H. Van Der Zee, E.P. Prens, Gert Folkerts, Jurr Boer

Research output: Contribution to journalBook/Film/Article reviewAcademic

Abstract

The focus of this review is to discuss the pathogenesis and the pharmacotherapy of Hidradenitis suppurativa (HS). HS is a distressing chronic skin disorder characterized by abscesses, boils, fistulas and scarring, generally affecting the groins, anogenital area and axillae. It is a common disease with an estimated prevalence of 1%. The etiology is unknown. HS was thought to be a disease of the apocrine sweat glands, but histological findings indicate that HS is a disease arising from the hair follicles. Several pathogenic factors seem important including genetic predisposition, smoking, obesity and an aberrant immune response to commensal flora. The management of HS is tremendously challenging because effective therapies are lacking. Nevertheless, HS has been treated with topical and systemic antibiotics, retinoids and immunosuppressive drugs such as anti-TNF-α biologics with partial success. In this review we will also discuss a potential new therapy for HS with the anti-psoriases agent acitretin. © 2011 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Journal of Pharmacology
Volume672
Issue number1-3
DOIs
Publication statusPublished - 15 Dec 2011

Keywords

  • Hidradenitis suppurativa
  • Inflammasome
  • Inflammatory mediator
  • Pharmacological intervention
  • Skin-inflammation
  • Toll-like receptor
  • adalimumab
  • androgen
  • antiandrogen
  • clindamycin
  • cyclosporin
  • cyproterone acetate
  • dapsone
  • doxycycline
  • etanercept
  • ethinylestradiol
  • etretin
  • etretinate
  • gamma secretase
  • infliximab
  • interleukin 6
  • interleukin 8
  • isotretinoin
  • membrane protein
  • metronidazole
  • minocycline
  • moxifloxacin
  • nicastrin
  • prednisolone
  • prednisone
  • presenilin 1
  • presenilin enhancer 2
  • rifampicin
  • tetracycline
  • tumor necrosis factor alpha
  • unclassified drug
  • unindexed drug
  • abscess drainage
  • antiinflammatory activity
  • apocrine gland
  • axilla
  • chromosome 1p
  • chromosome 1q
  • smoking
  • disease classification
  • drug mechanism
  • enzyme inhibition
  • family history
  • furunculosis
  • gene mutation
  • genetic predisposition
  • hair follicle
  • histopathology
  • human
  • immune response
  • immunomodulation
  • inguinal region
  • intestine flora
  • NCSTN gene
  • obesity
  • off label drug use
  • pathogenesis
  • patient care
  • prevalence
  • priority journal
  • protein synthesis inhibition
  • PSEN1 gene
  • PSENEN gene
  • review
  • skin abscess
  • skin fistula
  • skin scar
  • Staphylococcus
  • Streptococcus
  • suppurative hidradenitis

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