Abstract
Guinea pigs were inoculated intra-tracheally with bovine parainfluenza type 3 virus (PI-3) to investigate airway responsiveness to histamine and arecoline in vitro. Two days after saline or PI-3 inoculation no difference in the reactivity of the tracheal spirals was observed after cumulative concentration/response curves with both drugs. Similarly, contractions of parenchymal strips, induced by histamine, did not differ between both groups. However, 4 days after PI-3 inoculation the histamine induced contraction of the tracheal spirals was increased by 47% and the arecoline induced contractions by 32% as compared to the control group. Further, the contractions induced by histamine in parenchymal strips were significantly enhanced (p
Original language | English |
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Pages | 261-263 |
Number of pages | 3 |
Publication status | Published - 28 Mar 1990 |
Keywords
- arecoline
- histamine
- animal cell
- bronchospasm
- bronchus hyperreactivity
- conference paper
- guinea pig
- male
- nonhuman
- Human parainfluenza virus 3
- priority journal