Parainfluenza-3 induced hyperreactivity of the guinea pig trachea coincides with an increased number of broncho-alveolar cells

G. Folkerts, M. Janssen, F.P. Nijkamp

Research output: Contribution to conferenceAbstractOther research output

Abstract

Guinea pigs were inoculated intra-tracheally with bovine parainfluenza type 3 virus (PI-3) to investigate whether airway hyperreactivity was associated with an increase in the number of broncho-alveolar cells. Two days after saline or PI-3 inoculation no difference in histamine reactivity of the isolated tracheal spirals was observed. The number of broncho-alveolar cells was also not changed. However, 4 days after PI-3 inoculation the histamine-induced contraction of the tracheal spirals was increased by 45% and the number of inflammatory cells in the airways by 150% as compared with the control group. In conclusion, PI-3 infection of the guinea pig respiratory airways induces tracheal hyperreactivity which is associated with an increase in broncho-alveolar cells.
Original languageEnglish
Pages159S-161S
Publication statusPublished - 28 Mar 1990

Keywords

  • histamine
  • animal cell
  • animal experiment
  • breathing muscle
  • bronchus hyperreactivity
  • conference paper
  • guinea pig
  • lung alveolus cell
  • nonhuman
  • Human parainfluenza virus 3
  • priority journal

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