Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe

Fergus Allerton; Cameron Prior; Arzu Funda Bagcigil; Els Broens; Bénédicte Callens; Peter Damborg; Jeroen Dewulf; Maria-Eleni Filippitzi; Luís Pedro Carmo; Jonathan Gómez-Raja; Erez Harpaz; Ana Mateus; Mirja Nolff; Clare J Phythian; Dorina Timofte; Flavia Zendri; Lisbeth Rem Jessen

doi:10.3390/antibiotics10040409

Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe

Fergus Allerton
, Cameron Prior
, Arzu Funda Bagcigil
, Els Broens
, Bénédicte Callens
, Peter Damborg
, Jeroen Dewulf
, Maria-Eleni Filippitzi
, Luís Pedro Carmo
, Jonathan Gómez-Raja
, Erez Harpaz
, Ana Mateus
, Mirja Nolff
, Clare J Phythian
, Dorina Timofte
, Flavia Zendri
, Lisbeth Rem Jessen

Clinical Infectiology

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing antimicrobial resistance. The aim of this study was to map and qualitatively assess the ASGs for antimicrobial use in cats and dogs in Europe. Country representatives of the European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT) were asked to identify ASGs published in their countries. All collated ASGs updated since January 2010 containing recommendations on antimicrobial therapy for at least three conditions affecting different organ systems in cats and dogs underwent detailed review including AGREE II analysis. Out of forty countries investigated, fifteen ASGs from eleven countries met the inclusion criteria. Several critical principles of antimicrobial use were identified, providing a framework that should assist development of stewardship guidance. The AGREE II analysis highlighted several methodological limitations of the currently available ASGs. This study sheds light on the lack of national ASGs for dogs and cats in multiple European countries and should encourage national bodies to prioritize guideline development in small animals. A greater awareness of the need to use a structured approach to guideline development could improve the quality of ASGs in the future.

Original language	English
Article number	409
Number of pages	16
Journal	Antibiotics
Volume	10
Issue number	4
DOIs	https://doi.org/10.3390/antibiotics10040409
Publication status	Published - 9 Apr 2021

Bibliographical note

Funding Information:
Acknowledgments: This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Be¯rzin, š, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puvacˇa, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlović, Dragica Stojanović, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc.

Funding Information:
This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Berzin, ?, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puva?ca, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlov?c, Dragica Stojanov?c, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc.

Publisher Copyright:
© 2021 by the authors.

Keywords

AGREE II
Antimicrobial resistance
Antimicrobial stewardship
Canine
Feline
Guidelines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/antibiotics10040409

antibiotics-10-00409Final published version, 1.74 MB

Cite this

Allerton, F., Prior, C., Bagcigil, A. F., Broens, E., Callens, B., Damborg, P., Dewulf, J., Filippitzi, M.-E., Carmo, L. P., Gómez-Raja, J., Harpaz, E., Mateus, A., Nolff, M., Phythian, C. J., Timofte, D., Zendri, F., & Jessen, L. R. (2021). Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe. Antibiotics, 10(4), Article 409. https://doi.org/10.3390/antibiotics10040409

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title = "Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe",

abstract = "Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing antimicrobial resistance. The aim of this study was to map and qualitatively assess the ASGs for antimicrobial use in cats and dogs in Europe. Country representatives of the European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT) were asked to identify ASGs published in their countries. All collated ASGs updated since January 2010 containing recommendations on antimicrobial therapy for at least three conditions affecting different organ systems in cats and dogs underwent detailed review including AGREE II analysis. Out of forty countries investigated, fifteen ASGs from eleven countries met the inclusion criteria. Several critical principles of antimicrobial use were identified, providing a framework that should assist development of stewardship guidance. The AGREE II analysis highlighted several methodological limitations of the currently available ASGs. This study sheds light on the lack of national ASGs for dogs and cats in multiple European countries and should encourage national bodies to prioritize guideline development in small animals. A greater awareness of the need to use a structured approach to guideline development could improve the quality of ASGs in the future.",

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author = "Fergus Allerton and Cameron Prior and Bagcigil, \{Arzu Funda\} and Els Broens and B{\'e}n{\'e}dicte Callens and Peter Damborg and Jeroen Dewulf and Maria-Eleni Filippitzi and Carmo, \{Lu{\'i}s Pedro\} and Jonathan G{\'o}mez-Raja and Erez Harpaz and Ana Mateus and Mirja Nolff and Phythian, \{Clare J\} and Dorina Timofte and Flavia Zendri and Jessen, \{Lisbeth Rem\}",

note = "Funding Information: Acknowledgments: This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Be¯rzin, {\v s}, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puvacˇa, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlovi{\'c}, Dragica Stojanovi{\'c}, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc. Funding Information: This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Berzin, ?, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puva?ca, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlov?c, Dragica Stojanov?c, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc. Publisher Copyright: {\textcopyright} 2021 by the authors.",

year = "2021",

month = apr,

day = "9",

doi = "10.3390/antibiotics10040409",

language = "English",

volume = "10",

journal = "Antibiotics",

issn = "2079-6382",

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Allerton, F, Prior, C, Bagcigil, AF, Broens, E, Callens, B, Damborg, P, Dewulf, J, Filippitzi, M-E, Carmo, LP, Gómez-Raja, J, Harpaz, E, Mateus, A, Nolff, M, Phythian, CJ, Timofte, D, Zendri, F & Jessen, LR 2021, 'Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe', Antibiotics, vol. 10, no. 4, 409. https://doi.org/10.3390/antibiotics10040409

TY - JOUR

T1 - Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe

AU - Allerton, Fergus

AU - Prior, Cameron

AU - Bagcigil, Arzu Funda

AU - Broens, Els

AU - Callens, Bénédicte

AU - Damborg, Peter

AU - Dewulf, Jeroen

AU - Filippitzi, Maria-Eleni

AU - Carmo, Luís Pedro

AU - Gómez-Raja, Jonathan

AU - Harpaz, Erez

AU - Mateus, Ana

AU - Nolff, Mirja

AU - Phythian, Clare J

AU - Timofte, Dorina

AU - Zendri, Flavia

AU - Jessen, Lisbeth Rem

N1 - Funding Information: Acknowledgments: This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Be¯rzin, š, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puvacˇa, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlović, Dragica Stojanović, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc. Funding Information: This article is based upon work from the COST Action European Network for Optimization of Veterinary Antimicrobial Treatment (CA18217), supported by European Cooperation in Science and Technology (COST); see: www.enovat.eu and www.cost.eu, assessed date: 15 January 2021. The authors are especially grateful to ENOVAT country representatives and other contacts for completing the search for antimicrobial stewardship guidelines in their countries. Thanks to: Mentor Alishani, Ilias Apostolakos, Naim Deniz Ayaz, Luca Bano, Aivars Berzin, ?, Ferenc Biro, Lucia Birosova, Tereza Bodnorova, Myriam Borman, Petra Cagnardi, Giorgi Chakhunashvili, Sonila Cocoli, Elsa Leclerc Duarte, Clair Firth, Paola Grenni, Luca Guardabassi, Josipa Habus, Piret Kalmus, Eran Levy, Peter Kopp, Aneliya Milanova, Slavcho Mrenoshki, Aleksandr Novoslavskij, Charlotta Oddsdottir, Alessandra Piccirillo, Constanca Pomba, Nikola Puva?ca, Magdalena Rzewuska, Simone Schuller, Ahmed Smajlov?c, Dragica Stojanov?c, Pohjanvirta Tarja, Ana Vale, Romel Velev, Ulrika Windahl and Irena Zdovc. Publisher Copyright: © 2021 by the authors.

PY - 2021/4/9

Y1 - 2021/4/9

N2 - Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing antimicrobial resistance. The aim of this study was to map and qualitatively assess the ASGs for antimicrobial use in cats and dogs in Europe. Country representatives of the European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT) were asked to identify ASGs published in their countries. All collated ASGs updated since January 2010 containing recommendations on antimicrobial therapy for at least three conditions affecting different organ systems in cats and dogs underwent detailed review including AGREE II analysis. Out of forty countries investigated, fifteen ASGs from eleven countries met the inclusion criteria. Several critical principles of antimicrobial use were identified, providing a framework that should assist development of stewardship guidance. The AGREE II analysis highlighted several methodological limitations of the currently available ASGs. This study sheds light on the lack of national ASGs for dogs and cats in multiple European countries and should encourage national bodies to prioritize guideline development in small animals. A greater awareness of the need to use a structured approach to guideline development could improve the quality of ASGs in the future.

AB - Antimicrobial stewardship guidelines (ASGs) represent an important tool to help veterinarians optimize their antimicrobial use with the objective of decreasing antimicrobial resistance. The aim of this study was to map and qualitatively assess the ASGs for antimicrobial use in cats and dogs in Europe. Country representatives of the European Network for Optimization of Veterinary Antimicrobial Treatment (ENOVAT) were asked to identify ASGs published in their countries. All collated ASGs updated since January 2010 containing recommendations on antimicrobial therapy for at least three conditions affecting different organ systems in cats and dogs underwent detailed review including AGREE II analysis. Out of forty countries investigated, fifteen ASGs from eleven countries met the inclusion criteria. Several critical principles of antimicrobial use were identified, providing a framework that should assist development of stewardship guidance. The AGREE II analysis highlighted several methodological limitations of the currently available ASGs. This study sheds light on the lack of national ASGs for dogs and cats in multiple European countries and should encourage national bodies to prioritize guideline development in small animals. A greater awareness of the need to use a structured approach to guideline development could improve the quality of ASGs in the future.

KW - AGREE II

KW - Antimicrobial resistance

KW - Antimicrobial stewardship

KW - Canine

KW - Feline

KW - Guidelines

UR - https://www.scopus.com/pages/publications/85104418789

U2 - 10.3390/antibiotics10040409

DO - 10.3390/antibiotics10040409

M3 - Article

C2 - 33918617

SN - 2079-6382

VL - 10

JO - Antibiotics

JF - Antibiotics

IS - 4

M1 - 409

ER -

Overview and Evaluation of Existing Guidelines for Rational Antimicrobial Use in Small-Animal Veterinary Practice in Europe

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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