Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs

Irin Kwananocha; Joëll Magré; Amir Kamali; Femke Verseijden; Koen Willemsen; Yuntao Ji; Bart C.H. van der Wal; Ralph J.B. Sakkers; Marianna A. Tryfonidou; Björn P. Meij

doi:10.3390/ani14162385

Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs

Irin Kwananocha
, Joëll Magré
, Amir Kamali
, Femke Verseijden
, Koen Willemsen
, Yuntao Ji
, Bart C.H. van der Wal
, Ralph J.B. Sakkers
, Marianna A. Tryfonidou
, Björn P. Meij^*

^*Corresponding author for this work

Kasetsart University
Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia.

Original language	English
Article number	2385
Number of pages	18
Journal	Animals
Volume	14
Issue number	16
DOIs	https://doi.org/10.3390/ani14162385
Publication status	Published - 17 Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 by the authors.

Funding

The research received financial support from various grants, including the European Investment Funds Interreg VA Flanders, endorsed by the Ministry of Economic Affairs (NL) and the Provinces of Limburg (NL) and Flemish-Brabant (B) for the PRosPERoS (Printing Personalized Orthopaedic Implants) project. Additionally, funding was provided by charity funds allocated to Friends of VetMed (Vrienden Diergeneeskunde) for the execution of the clinical dog study, including contributions from the K.F.Hein Fonds; Dinamo Fonds; Stichting Nijdier; Stichting Meijer Boekbinder Fonds, and Stichting Het Waardige Dier. Moreover, this research received financial support from the Dutch Arthritis Society (LLP22 and LLP12). The CT instrument at the Multi-scale Imaging and Tomography Facility (MINT) of Utrecht University was funded by the Netherlands Research Council (NWO) via the EPOS-NL Research Infrastructure program. Furthermore, IK is the recipient of a scholarship from the Faculty of Veterinary Medicine, Kasetsart University, Thailand.

Funders	Funder number
European Investment Funds Interreg VA Flanders
Provinces of Limburg
Stichting Meijer Boekbinder Fonds
Dutch Arthritis Society	LLP22, LLP12
Netherlands Research Council (NWO) via the EPOS-NL Research Infrastructure program
Faculty of Veterinary Medicine, Kasetsart University, Thailand

Keywords

3D printed implant
ACE-X
acetabular rim extension
customized implant
dog
femoral head coverage
hip dysplasia

Access to Document

10.3390/ani14162385Licence: CC BY

animals-14-02385Final published version, 4.79 MBLicence: CC BY

Cite this

@article{481ab358170542b4a10da6df0e013aa8,

title = "Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs",

abstract = "The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani{\textquoteright}s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8\%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90\% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia.",

keywords = "3D printed implant, ACE-X, acetabular rim extension, customized implant, dog, femoral head coverage, hip dysplasia",

author = "Irin Kwananocha and Jo{\"e}ll Magr{\'e} and Amir Kamali and Femke Verseijden and Koen Willemsen and Yuntao Ji and \{van der Wal\}, \{Bart C.H.\} and Sakkers, \{Ralph J.B.\} and Tryfonidou, \{Marianna A.\} and Meij, \{Bj{\"o}rn P.\}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = aug,

day = "17",

doi = "10.3390/ani14162385",

language = "English",

volume = "14",

journal = "Animals",

issn = "2076-2615",

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T1 - Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs

AU - Kwananocha, Irin

AU - Magré, Joëll

AU - Kamali, Amir

AU - Verseijden, Femke

AU - Willemsen, Koen

AU - Ji, Yuntao

AU - van der Wal, Bart C.H.

AU - Sakkers, Ralph J.B.

AU - Tryfonidou, Marianna A.

AU - Meij, Björn P.

PY - 2024/8/17

Y1 - 2024/8/17

N2 - The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia.

AB - The acetabular rim extension (ACE-X) implant is a custom-made three-dimensionally printed titanium device designed for the treatment of canine hip dysplasia. In this study, 34 dogs (61 hips) underwent ACE-X implantation, and assessments were conducted using computed tomography, force plate analysis, Ortolani’s test, and the Helsinki chronic pain index (HCPI) questionnaires at five intervals: the pre-operative day, the surgery day, and the 1.5-month, 3-month, and 12-month follow-ups. Statistically significant increases in femoral head coverage with a negative Ortolani subluxation test were observed immediately after surgery and persisted throughout the study. Osteoarthritis (OA) scores remained stable, but osteophyte size significantly increased between the surgery day and the 12-month follow-up, especially in hips with a baseline OA score of 2 compared to those with a score of 1. The force plate data showed no significant changes during the study. The HCPI demonstrated a significant decrease in pain score from pre-operative value to six-week follow-up and gradually decreased over time. Major complications were identified in six hips (9.8%) of four dogs. In conclusion, the ACE-X implant effectively increased femoral head coverage, eliminated subluxation, and provided long-term pain relief with minimal complications, benefiting over 90% of the study population. The study supports the ACE-X implant as a valuable alternative treatment for canine hip dysplasia.

KW - 3D printed implant

KW - ACE-X

KW - acetabular rim extension

KW - customized implant

KW - dog

KW - femoral head coverage

KW - hip dysplasia

UR - https://www.scopus.com/pages/publications/85202587226

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DO - 10.3390/ani14162385

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VL - 14

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JF - Animals

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M1 - 2385

ER -

Outcome One Year after Acetabular Rim Extension Using a Customized Titanium Implant for Treating Hip Dysplasia in Dogs

Abstract

Bibliographical note

Funding

Keywords

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