Organelle distribution in neurons: Logistics behind polarized transport

Max Koppers; Ginny G Farías

doi:10.1016/j.ceb.2021.02.004

Organelle distribution in neurons: Logistics behind polarized transport

Max Koppers, Ginny G Farías^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Highly polarized neurons need to carefully regulate the distribution of organelles and other cargoes into their two morphologically and functionally distinct domains, the somatodendritic and axonal compartments, to maintain proper neuron homeostasis. An outstanding question in the field is how organelles reach their correct destination. Long-range transport along microtubules, driven by motors, ensures a fast and controlled availability of organelles in axons and dendrites, but it remains largely unclear what rules govern their transport into the correct compartment. Here, we review the emerging concepts of polarized cargo trafficking in neurons, highlighting the role of microtubule organization, microtubule-associated proteins, and motor proteins and discuss compartment-specific inclusion and exclusion mechanisms as well as the regulation of correct coupling of cargoes to motor proteins.

Original language	English
Pages (from-to)	46-54
Number of pages	9
Journal	Current Opinion in Cell Biology
Volume	71
DOIs	https://doi.org/10.1016/j.ceb.2021.02.004
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
This review was supported by funding from the Netherlands Organization for Scientific Research (NWO) through a VIDI grant (016.VIDI.189.019) and KLEIN grant (OCENW.KLEIN.236) to G.G.F. and a VENI grant (VI.Veni.202.113) to M.K.

Publisher Copyright:
© 2021 The Author(s)

Keywords

AIS
MAPs
MT organization
Motor adaptors
Motors
Neurons
Organelle contacts
Organelles
PAEZ
Polarized transport
Proximal axon

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10.1016/j.ceb.2021.02.004

1-s2.0-S0955067421000259-mainFinal published version, 1.33 MBLicence: CC BY

Cite this

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title = "Organelle distribution in neurons: Logistics behind polarized transport",

abstract = "Highly polarized neurons need to carefully regulate the distribution of organelles and other cargoes into their two morphologically and functionally distinct domains, the somatodendritic and axonal compartments, to maintain proper neuron homeostasis. An outstanding question in the field is how organelles reach their correct destination. Long-range transport along microtubules, driven by motors, ensures a fast and controlled availability of organelles in axons and dendrites, but it remains largely unclear what rules govern their transport into the correct compartment. Here, we review the emerging concepts of polarized cargo trafficking in neurons, highlighting the role of microtubule organization, microtubule-associated proteins, and motor proteins and discuss compartment-specific inclusion and exclusion mechanisms as well as the regulation of correct coupling of cargoes to motor proteins.",

keywords = "AIS, MAPs, MT organization, Motor adaptors, Motors, Neurons, Organelle contacts, Organelles, PAEZ, Polarized transport, Proximal axon",

author = "Max Koppers and Far{\'i}as, {Ginny G}",

note = "Funding Information: This review was supported by funding from the Netherlands Organization for Scientific Research (NWO) through a VIDI grant (016.VIDI.189.019) and KLEIN grant (OCENW.KLEIN.236) to G.G.F. and a VENI grant (VI.Veni.202.113) to M.K. Publisher Copyright: {\textcopyright} 2021 The Author(s)",

year = "2021",

month = aug,

doi = "10.1016/j.ceb.2021.02.004",

language = "English",

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T2 - Logistics behind polarized transport

AU - Koppers, Max

AU - Farías, Ginny G

N1 - Funding Information: This review was supported by funding from the Netherlands Organization for Scientific Research (NWO) through a VIDI grant (016.VIDI.189.019) and KLEIN grant (OCENW.KLEIN.236) to G.G.F. and a VENI grant (VI.Veni.202.113) to M.K. Publisher Copyright: © 2021 The Author(s)

PY - 2021/8

Y1 - 2021/8

N2 - Highly polarized neurons need to carefully regulate the distribution of organelles and other cargoes into their two morphologically and functionally distinct domains, the somatodendritic and axonal compartments, to maintain proper neuron homeostasis. An outstanding question in the field is how organelles reach their correct destination. Long-range transport along microtubules, driven by motors, ensures a fast and controlled availability of organelles in axons and dendrites, but it remains largely unclear what rules govern their transport into the correct compartment. Here, we review the emerging concepts of polarized cargo trafficking in neurons, highlighting the role of microtubule organization, microtubule-associated proteins, and motor proteins and discuss compartment-specific inclusion and exclusion mechanisms as well as the regulation of correct coupling of cargoes to motor proteins.

AB - Highly polarized neurons need to carefully regulate the distribution of organelles and other cargoes into their two morphologically and functionally distinct domains, the somatodendritic and axonal compartments, to maintain proper neuron homeostasis. An outstanding question in the field is how organelles reach their correct destination. Long-range transport along microtubules, driven by motors, ensures a fast and controlled availability of organelles in axons and dendrites, but it remains largely unclear what rules govern their transport into the correct compartment. Here, we review the emerging concepts of polarized cargo trafficking in neurons, highlighting the role of microtubule organization, microtubule-associated proteins, and motor proteins and discuss compartment-specific inclusion and exclusion mechanisms as well as the regulation of correct coupling of cargoes to motor proteins.

KW - AIS

KW - MAPs

KW - MT organization

KW - Motor adaptors

KW - Motors

KW - Neurons

KW - Organelle contacts

KW - Organelles

KW - PAEZ

KW - Polarized transport

KW - Proximal axon

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U2 - 10.1016/j.ceb.2021.02.004

DO - 10.1016/j.ceb.2021.02.004

M3 - Article

C2 - 33706233

SN - 0955-0674

VL - 71

SP - 46

EP - 54

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Organelle distribution in neurons: Logistics behind polarized transport

Abstract

Bibliographical note

Keywords

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