Optimizing divalent inhibitors of pseudomonas aeruginosa lectin leca by using a rigid spacer

Francesca Pertici; Nico J. De Mol; Johan Kemmink; Roland J. Pieters

doi:10.1002/chem.201303463

Optimizing divalent inhibitors of pseudomonas aeruginosa lectin leca by using a rigid spacer

Francesca Pertici, Nico J. De Mol, Johan Kemmink, Roland J. Pieters

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Rigid spacers: Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose-triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500-fold enhancement in potency. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	16923-16927
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	50
DOIs	https://doi.org/10.1002/chem.201303463
Publication status	Published - 9 Dec 2013

Keywords

adhesin
antiinfective agent
carbohydrate
glycoconjugate
LecA protein, bacteria
lectin
article
chemistry
multivalency
Pseudomonas aeruginosa
rigid spacers

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10.1002/chem.201303463

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abstract = "Rigid spacers: Optimal highly potent divalent ligands of the P. aeruginosa lectin LecA have been prepared. The ligands consist of a rigid spacer derived from glucose-triazole units (see figure). Systematic variation of the number of spacer units and the aglycon linker led to a 7500-fold enhancement in potency. {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

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author = "Francesca Pertici and {De Mol}, {Nico J.} and Johan Kemmink and Pieters, {Roland J.}",

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AU - Pertici, Francesca

AU - De Mol, Nico J.

AU - Kemmink, Johan

AU - Pieters, Roland J.

PY - 2013/12/9

Y1 - 2013/12/9

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KW - adhesin

KW - antiinfective agent

KW - carbohydrate

KW - glycoconjugate

KW - LecA protein, bacteria

KW - lectin

KW - article

KW - chemistry

KW - multivalency

KW - Pseudomonas aeruginosa

KW - rigid spacers

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 50

ER -

Optimizing divalent inhibitors of pseudomonas aeruginosa lectin leca by using a rigid spacer

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Keywords

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