Open access is tiring out peer reviewers

Scientists like to complain about peer review. No researcher wants to be told that their work is flawed, unworthy or just plain wrong. But in recent months, I received reviews of my own submitted papers that suggest reviewers simply did not read the manuscript properly.
This is not nitpicking over matters of opinion or interpretation. In one instance, a reviewer complimented the double-blind placebo-controlled nature of our study, and made methodological comments related to that. Yet the study was not placebo controlled. In fact, participants were randomly assigned to three different active treatments. That is a serious mistake and undermines the supposed internal quality control of the peer-review system.
Conversations with colleagues reveal similar concerns about peer-review quality, and suggest that the scale of the problem has increased over the past few years. These are anecdotal reports, but they do raise a serious question: as the number of academic papers and scientific journals published continues to grow, can the peer-review system cope?